Particulate matter exposure shapes DNA methylation through the lifespan

Ferrari, L.; Carugno, M.; Bollati, V.

doi:10.1186/s13148-019-0726-x

Clinical Epigenetics

Table 1 Particulate matter effects on DNA methylation, in different life stages

From: Particulate matter exposure shapes DNA methylation through the lifespan

Life stage	↑/↓*	Genes	Type	Tissue	Ref.	Number
Preconceptional	↑	Global	Mouse	Sperm	Yauk et al. (2008)	[14]
Pregnancy, first trimester	↑	LINE-1	Human	Blood spots	Breton et al. (2016)	[15]
Pregnancy, first trimester	↓	Global	Human	Placenta	Janssen et al. (2013)	[16]
Pregnancy, first trimester	↓	LINE-1	Human	Placenta	Cai et al. (2017)	[17]
Pregnancy	↓	LINE-1	Human	Placenta	Kingsley et al. (2016)	[18]
Pregnancy	↑↓	7 CpG sites (i.e., three located near PTPRN2, TMEM125, and VPS4A genes, the other 4 sites mapped to non-genic regions)	Human	Placenta	Kingsley et al. (2016)	[18]
Pregnancy, first and second trimester	↑	HSD11B2	Human	Placenta	Oakley and Cidlowski (2013)	[19]
Pregnancy, second trimester	↑	SOD2	Human	Cord blood and maternal blood	Zhou et al. (2019)	[20]
Pregnancy	↑↓	APEX1, OGG1, ERCC4, TP53 DAPK1	Human	Placenta	Neven et al. (2018)	[21]
Pregnancy, third trimester	↑	NPAS2, CRY1, PER2, PER3	Human	Placenta	Nawrot et al. (2018)	[22]
Pregnancy, first trimester	↑	D-loop, MT-RNR1	Human	Placenta	Janssen et al. (2015)	[23]
Childhood, asthma	↓	Immune genes (e.g., IL13 and RUNX3)	Human	Blood	Yang et al. (2015)	[24]
Childhood, asthma	↑	FOXP3	Human	Blood	Prunicki et al. (2018)	[25]
Childhood	↓	IL-4, IFN-γ	Human	Blood	Jung et al. (2017)	[26]
Childhood	↓	TET1	Human	Nasal airway cells	Somineni et al. (2016)	[27]
Childhood	↑	FAM13A, NOTCH4	Human	Blood	Gruzieva et al. (2019)	[28]
Adult age, healthy	↑↓	MATN4, ARPP21, CFTR	Human	Blood	Gondalia et al. (2019)	[29]
Adult age, obese	↓	CD14, TLR4	Human	Blood	Cantone et al. (2017)	[30]
Adult age, occupational exposure	↓	NOS3, EDN1	Human	Blood	Tarantini et al. (2013)	[31]
Adult age, CVD	↑↓	cg20455854, cg07855639, cg07598385, cg17360854, cg23599683	Human	Blood	Chi et al. (2016)	[32]
Adult age, CVD	↓	Global	Human	Blood	Plusquin et al. (2017)	[33]
Adult age, CVD	↓	Alu, TLR4	Human, crossover	Blood	Bellavia et al. (2013)	[34]
Adult age, CVD	↑	IFN-γ	Human, crossover	Blood	Tobaldini et al. (2018)	[35]
Adult age, CVD	↑↓	Loci related to insulin resistance, glucose and lipid metabolism, inflammation, oxidative stress, platelet activation, and cell survival and apoptosis	Human, crossover	Blood	Li et al. (2018)	[36]
Adult age, CVD	↑↓	Loci related to apoptosis, cell death and metabolic pathways, or associated with ion binding and shuttling	In vitro	Human cardiomyocytes AC16	Yang et al. (2018)	[37]
Adult age, respiratory disease	↑↓	2827 CpG sites (genes involved in inflammation and oxidative stress response), repetitive elements, and microRNA	Human, crossover	Blood	Jiang et al. (2014)	[38]
Adult age, respiratory disease	↑↓	12 differentially methylated probes and 27 differentially methylated regions	Human	Blood	Lee et al. (2019)	[39]
Adult age, cancer	↑	P16^INK4A	In vitro	Ex vivo lymphocytes	Fougere et al. (2018)	[40]
Adult age, cancer	↑	P16^INK4A	In vitro	Primary human bronchial epithelial cells	Leclercq et al. (2017)	[41]
Adult age, cancer	↑↓	66 genes	In vitro	BEAS-2B cells	Hesselbach et al. (2017)	[42]
Adult age, cancer	↑↓	P16^INK4A, APC, LINE-1, NOS2	Mouse	Blood	Ding et al. (2016)	[43]
Adult age, cancer, DOHaD	↑↓	SYK, CCND2	Human	Blood	Callahan et al. (2018)	[44]
Adult age	↑	MT-TF, MT-RNR1	Human	Blood	Byun et al. (2013)	[45]
Adult age	↓	D-loop	Human	Blood	Byun et al. (2016)	[46]
Elderly	↑↓	Genes involved in tumor development, gene regulation, inflammatory stimuli, pulmonary disorders, and glucose metabolism	Human	Blood	Panni et al. (2016)	[47]
Elderly	↑↓	LINE-1, Alu, IL-6	Human	Blood	Bind et al. (2012)	[48]
Elderly	↓	iNOS	Human	Blood	Madrigano et al. (2012)	[49]

*Increase (↑) or decrease (↓) in DNA methylation

Back to article page

ISSN: 1868-7083

Contact us

Submission enquiries: avalyn.villar@springernature.com
General enquiries: info@biomedcentral.com