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Fig. 6 | Clinical Epigenetics

Fig. 6

From: DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer

Fig. 6

DNA methylome-wide analysis of DMPs in MCF-7 cells treated with BPA, BPF, and BPS ± ERI. Differentially methylated probes (DMPs) were analyzed in MCF-7 cells treated for 48 h with functional doses of BPA, BPF, and BPS with or without ERI and ERI alone when compared to control. Venn diagrams of DMPs and genes encompassing DMPs of BPA ± ERI, BPF ± ERI, and BPS ± ERI are shown in A1A6, B1B6, and C1C6, respectively. Representative figures of DMPs (genes) altered by BPA, BPF, or BPS treatment conditions and being dependent on (A7, B7, C7), partially dependent on (A8, B8, C8), or completely independent of (A9, B9, C9) ERI, respectively. Data are presented as mean ± standard deviation (SD) of two independent trials. Comparisons were performed between each treatment condition and corresponding control using robust linear model (RLM) (*p value < 0.05)

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