Fig. 5

DNA methylome-wide analysis of DMPs in MCF-7 cells treated with BPA, BPF, and BPS. Differentially methylated probes (DMPs) were analyzed in MCF-7 cells treated for 48 h with exposure and functional doses of BPA, BPF, and BPS treatment conditions when compared to control. Venn diagrams of DMPs and genes encompassing DMPs of BPA, BPF, or BPS are shown in A1–A3 and B1–B3, respectively. Pathways of genes encompassing DMPs of BPA, BPF, and BPS were detected based on KEGG pathway database using Enrichr (http://amp.pharm.mssm.edu/Enrichr/) and shown in C1 and C2. BPF was not included in C2, because its DMP-derived genes were not significantly involved in any pathway (as shown in C1)