Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

Tajuddin, Salman M.; Hernandez, Dena G.; Chen, Brian H.; Noren Hooten, Nicole; Mode, Nicolle A.; Nalls, Mike A.; Singleton, Andrew B.; Ejiogu, Ngozi; Chitrala, Kumaraswamy Naidu; Zonderman, Alan B.; Evans, Michele K.

doi:10.1186/s13148-019-0722-1

Table 2 Novel age-associated differentially methylated CpG positions (aDMPs) identified using the MethylationEPIC BeadChip

From: Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

I. African Americans								II. Whites
IlmnID	Chr	BP position	Gene	Relation to island	Beta	SE	P	IlmnID	Chr	BP position	Gene	Relation to island	Beta	SE	P
vcg17268658	chr2	106015745	*FHL2*	Island	0.019	0.001	2.37E−36	cg27099280	chr15	72612204	*CELF6*	Island	0.044	0.004	7.19E−26
cg27099280	chr15	72612204	*CELF6*	Island	0.041	0.003	1.88E−31	cg06210197	chr8	24771256	*NEFM*	Island	0.029	0.003	2.70E−23
cg13206721	chr10	25463350	*GPR158*	N_Shore	0.023	0.002	4.91E−31	cg26947034	chr7	33935438		OpenSea	− 0.020	0.002	3.43E−21
cg26947034	chr7	33935438		OpenSea	− 0.022	0.002	5.28E−27	cg24214068	chr8	24771265	*NEFM*	Island	0.018	0.002	4.77E−21
cg19644580	chr21	19166676	C21orf91	OpenSea	− 0.016	0.001	6.83E−27	cg12841266	chr3	9594093	*LHFPL4*	Island	0.014	0.002	9.94E−20
cg21620282	chr14	93389628	*CHGA*	Island	0.023	0.002	5.93E−26	cg07323488	chr3	168185313	*EGFEM1P*	OpenSea	− 0.025	0.003	1.84E−19
cg12841266	chr3	9594093	*LHFPL4*	Island	0.015	0.001	1.62E−25	cg17268658	chr2	106015745	*FHL2*	Island	0.016	0.002	3.25E−18
cg13552692	chr18	66389447	*CCDC102B*	OpenSea	− 0.020	0.002	6.11E−24	cg21620282	chr14	93389628	*CHGA*	Island	0.020	0.002	5.44E−18
cg07504615	chr3	14832729		OpenSea	− 0.014	0.001	1.44E−22	cg17740900	chr14	64266659		OpenSea	− 0.033	0.004	1.98E−17
cg24214068	chr8	24771265	*NEFM*	Island	0.019	0.002	1.18E−20	cg03947688	chr5	79866382	*ANKRD34B*	Island	0.017	0.002	6.05E−17
cg12642568	chr1	1846648	*CALML6*	N_Shelf	− 0.013	0.001	1.56E−20	cg13206721	chr10	25463350	*GPR158*	N_Shore	0.021	0.003	1.09E−16
cg14911690	chr19	19729395	PBX4	Island	0.021	0.002	7.31E−20	cg13552692	chr18	66389447	*CCDC102B*	OpenSea	− 0.021	0.003	1.53E−16
cg21165089	chr11	64739736	C11orf85	Island	0.014	0.002	1.52E−19	cg02669012	chr10	58382013		OpenSea	− 0.023	0.003	2.24E−16
cg22116858	chr10	105241934	NEURL1-AS1	OpenSea	− 0.012	0.001	1.75E−19	cg12642568	chr1	1846648	*CALML6*	N_Shelf	− 0.012	0.002	1.16E−15
cg12211691	chr1	32211779	ADGRB2	S_Shelf	− 0.014	0.002	2.43E−19	cg27447795	chr1	46309093	MAST2	OpenSea	− 0.029	0.004	1.28E−15
cg04640687	chr13	102844744	*FGF14*	OpenSea	− 0.030	0.003	3.21E−19	cg26081188	chr11	19726873	*NAV2*	OpenSea	− 0.017	0.002	1.70E−15
cg21323642	chr22	31709724		OpenSea	− 0.015	0.002	6.31E−19	cg23565569	chr7	120629502	CPED1	OpenSea	− 0.025	0.003	2.13E−15
cg18758922	chr22	37099785	CACNG2	S_Shore	0.017	0.002	1.29E−18	cg24866418	chr3	9594082	*LHFPL4*	Island	0.012	0.002	4.11E−15
cg01156568	chr6	87849235		OpenSea	− 0.027	0.003	1.49E−18	cg04640687	chr13	102844744	*FGF14*	OpenSea	− 0.034	0.004	5.30E−15
cg16832267	chr2	18060102	KCNS3	Island	0.039	0.005	1.99E−18	cg07024568	chr15	71615957	THSD4	OpenSea	− 0.026	0.003	1.10E−14
cg04931708	chr7	121944678	FEZF1	S_Shore	0.023	0.003	2.96E−18	cg01763090	chr15	31775406	OTUD7A	N_Shore	0.017	0.002	1.11E−14
cg26928911	chr1	22968992	*C1QC*	OpenSea	− 0.018	0.002	3.42E−18	cg21757266	chr13	28896815	FLT1	OpenSea	− 0.020	0.003	2.29E−14
cg24964298	chr1	155959036		OpenSea	− 0.012	0.001	3.60E−18	cg22353329	chr17	77814357	CBX4	Island	0.024	0.003	2.57E−14
cg07132386	chr2	207139218	*ZDBF2*	N_Shore	0.024	0.003	3.82E−18	cg25273039	chr7	8473512	NXPH1	Island	0.015	0.002	3.82E−14
cg24866418	chr3	9594082	*LHFPL4*	Island	0.013	0.002	4.00E−18	cg08745595	chr1	169556012	F5	OpenSea	− 0.014	0.002	7.76E−14
cg16001722	chr6	127836159	C6orf174	Island	0.027	0.003	5.16E−18	cg26638716	chr14	80053724	NRXN3	OpenSea	− 0.025	0.003	8.01E−14
cg27037708	chr20	4721316	PRNT	OpenSea	− 0.017	0.002	5.44E−18	cg12318914	chr4	17387235		OpenSea	− 0.026	0.003	1.28E−13
cg08637691	chr9	134989631		OpenSea	0.021	0.002	5.48E−18	cg11102031	chr6	148060358		OpenSea	− 0.015	0.002	1.76E−13
cg02669012	chr10	58382013		OpenSea	− 0.019	0.002	6.34E−18	cg25181130	chr17	30651431	RHBDL3	OpenSea	− 0.020	0.003	2.77E−13
cg24501701	chr12	63544040	AVPR1A	Island	0.013	0.001	9.79E−18	cg09461021	chr22	20969574		OpenSea	− 0.018	0.002	3.11E−13
cg15628888	chr15	72612209	CELF6	Island	0.028	0.003	1.08E−17	cg07504615	chr3	14832729		OpenSea	− 0.013	0.002	4.99E−13
cg07323488	chr3	168185313	*EGFEM1P*	OpenSea	− 0.021	0.002	2.30E−17	cg09445550	chr20	5106966	PCNA	N_Shore	− 0.015	0.002	6.90E−13
cg17891166	chr7	73441989	ELN	OpenSea	− 0.014	0.002	2.87E−17	cg06506328	chr10	69373205	CTNNA3	OpenSea	− 0.021	0.003	7.25E−13
cg04978384	chr15	58358310	*ALDH1A2*	Island	0.027	0.003	4.62E−17	cg08176240	chr15	31489071		OpenSea	− 0.016	0.002	7.42E−13
cg03947688	chr5	79866382	*ANKRD34B*	Island	0.015	0.002	4.68E−17	cg18805621	chr4	10583796	CLNK	OpenSea	− 0.018	0.003	1.16E−12
cg12318914	chr4	17387235		OpenSea	− 0.026	0.003	5.64E−17	cg00067981	chr21	27254444	APP	OpenSea	− 0.011	0.002	1.44E−12
cg22558303	chr13	96705786	UGGT2	Island	0.038	0.005	6.53E−17	cg17554862	chr2	201991544	CFLAR	OpenSea	− 0.013	0.002	2.17E−12
cg00394316	chr7	22539822	MGC87042	Island	0.034	0.004	6.73E−17	cg21323642	chr22	31709724		OpenSea	− 0.011	0.002	2.30E−12
cg00101260	chr17	53426657		OpenSea	− 0.013	0.002	6.81E−17	cg16476710	chr14	37304393	SLC25A21	OpenSea	− 0.026	0.004	2.40E−12
cg18284157	chr22	37099802	CACNG2	S_Shore	0.017	0.002	8.96E−17	cg04978384	chr15	58358310	*ALDH1A2*	Island	0.025	0.004	2.65E−12
cg09849302	chr21	38378433	RIPPLY3	Island	0.020	0.002	1.73E−16	cg16381169	chr21	16031542		OpenSea	− 0.014	0.002	2.78E−12
cg26153045	chr7	73441834	ELN	OpenSea	− 0.015	0.002	2.17E−16	cg20193323	chr6	7276020		OpenSea	− 0.027	0.004	3.21E−12
cg26081188	chr11	19726873	*NAV2*	OpenSea	− 0.017	0.002	2.42E−16	cg16169166	chr3	14303148		OpenSea	− 0.021	0.003	3.36E−12
cg21328810	chr19	50829227	KCNC3	Island	0.013	0.002	2.59E−16	cg10934519	chr3	69720954		OpenSea	− 0.015	0.002	3.99E−12
cg25258740	chr12	75603230	KCNC2	Island	0.032	0.004	2.60E−16	cg17365308	chr12	126536415		OpenSea	− 0.020	0.003	5.40E−12
cg07522171	chr7	28218686	JAZF1-AS1	N_Shore	− 0.015	0.002	2.92E−16	cg26772387	chr15	91846753		OpenSea	− 0.013	0.002	5.96E−12
cg20168635	chr15	83916827		OpenSea	− 0.017	0.002	4.28E−16	cg26928911	chr1	22968992	*C1QC*	OpenSea	− 0.016	0.002	7.05E−12
cg25045526	chr7	121944506	FEZF1	Island	0.019	0.002	4.84E−16	cg09579833	chr3	49849871	UBA7	OpenSea	− 0.013	0.002	7.37E−12
cg26079664	chr3	51740956	GRM2	Island	0.028	0.003	5.18E−16	cg07132386	chr2	207139218	*ZDBF2*	N_Shore	0.018	0.003	8.17E−12
cg06210197	chr8	24771256	*NEFM*	Island	0.023	0.003	5.29E−16	cg01156568	chr6	87849235		OpenSea	− 0.022	0.003	1.15E−11

IlmnID: CpG probe identification number, SE: standard error
*Overlapping age-associated differentially methylated CpG positions between African Americans and whites are highlighted in bold

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ISSN: 1868-7083

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