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Table 2 Novel age-associated differentially methylated CpG positions (aDMPs) identified using the MethylationEPIC BeadChip

From: Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites

I. African Americans II. Whites
IlmnID Chr BP position Gene Relation to island Beta SE P IlmnID Chr BP position Gene Relation to island Beta SE P
vcg17268658 chr2 106015745 FHL2 Island 0.019 0.001 2.37E−36 cg27099280 chr15 72612204 CELF6 Island 0.044 0.004 7.19E−26
cg27099280 chr15 72612204 CELF6 Island 0.041 0.003 1.88E−31 cg06210197 chr8 24771256 NEFM Island 0.029 0.003 2.70E−23
cg13206721 chr10 25463350 GPR158 N_Shore 0.023 0.002 4.91E−31 cg26947034 chr7 33935438   OpenSea − 0.020 0.002 3.43E−21
cg26947034 chr7 33935438   OpenSea − 0.022 0.002 5.28E−27 cg24214068 chr8 24771265 NEFM Island 0.018 0.002 4.77E−21
cg19644580 chr21 19166676 C21orf91 OpenSea 0.016 0.001 6.83E27 cg12841266 chr3 9594093 LHFPL4 Island 0.014 0.002 9.94E−20
cg21620282 chr14 93389628 CHGA Island 0.023 0.002 5.93E−26 cg07323488 chr3 168185313 EGFEM1P OpenSea − 0.025 0.003 1.84E−19
cg12841266 chr3 9594093 LHFPL4 Island 0.015 0.001 1.62E−25 cg17268658 chr2 106015745 FHL2 Island 0.016 0.002 3.25E−18
cg13552692 chr18 66389447 CCDC102B OpenSea − 0.020 0.002 6.11E−24 cg21620282 chr14 93389628 CHGA Island 0.020 0.002 5.44E−18
cg07504615 chr3 14832729   OpenSea − 0.014 0.001 1.44E−22 cg17740900 chr14 64266659   OpenSea 0.033 0.004 1.98E17
cg24214068 chr8 24771265 NEFM Island 0.019 0.002 1.18E−20 cg03947688 chr5 79866382 ANKRD34B Island 0.017 0.002 6.05E−17
cg12642568 chr1 1846648 CALML6 N_Shelf − 0.013 0.001 1.56E−20 cg13206721 chr10 25463350 GPR158 N_Shore 0.021 0.003 1.09E−16
cg14911690 chr19 19729395 PBX4 Island 0.021 0.002 7.31E20 cg13552692 chr18 66389447 CCDC102B OpenSea − 0.021 0.003 1.53E−16
cg21165089 chr11 64739736 C11orf85 Island 0.014 0.002 1.52E19 cg02669012 chr10 58382013   OpenSea − 0.023 0.003 2.24E−16
cg22116858 chr10 105241934 NEURL1-AS1 OpenSea 0.012 0.001 1.75E19 cg12642568 chr1 1846648 CALML6 N_Shelf − 0.012 0.002 1.16E−15
cg12211691 chr1 32211779 ADGRB2 S_Shelf 0.014 0.002 2.43E19 cg27447795 chr1 46309093 MAST2 OpenSea 0.029 0.004 1.28E15
cg04640687 chr13 102844744 FGF14 OpenSea − 0.030 0.003 3.21E−19 cg26081188 chr11 19726873 NAV2 OpenSea − 0.017 0.002 1.70E−15
cg21323642 chr22 31709724   OpenSea − 0.015 0.002 6.31E−19 cg23565569 chr7 120629502 CPED1 OpenSea 0.025 0.003 2.13E15
cg18758922 chr22 37099785 CACNG2 S_Shore 0.017 0.002 1.29E18 cg24866418 chr3 9594082 LHFPL4 Island 0.012 0.002 4.11E−15
cg01156568 chr6 87849235   OpenSea − 0.027 0.003 1.49E−18 cg04640687 chr13 102844744 FGF14 OpenSea − 0.034 0.004 5.30E−15
cg16832267 chr2 18060102 KCNS3 Island 0.039 0.005 1.99E18 cg07024568 chr15 71615957 THSD4 OpenSea 0.026 0.003 1.10E14
cg04931708 chr7 121944678 FEZF1 S_Shore 0.023 0.003 2.96E18 cg01763090 chr15 31775406 OTUD7A N_Shore 0.017 0.002 1.11E14
cg26928911 chr1 22968992 C1QC OpenSea − 0.018 0.002 3.42E−18 cg21757266 chr13 28896815 FLT1 OpenSea 0.020 0.003 2.29E14
cg24964298 chr1 155959036   OpenSea 0.012 0.001 3.60E18 cg22353329 chr17 77814357 CBX4 Island 0.024 0.003 2.57E14
cg07132386 chr2 207139218 ZDBF2 N_Shore 0.024 0.003 3.82E−18 cg25273039 chr7 8473512 NXPH1 Island 0.015 0.002 3.82E14
cg24866418 chr3 9594082 LHFPL4 Island 0.013 0.002 4.00E−18 cg08745595 chr1 169556012 F5 OpenSea 0.014 0.002 7.76E14
cg16001722 chr6 127836159 C6orf174 Island 0.027 0.003 5.16E18 cg26638716 chr14 80053724 NRXN3 OpenSea 0.025 0.003 8.01E14
cg27037708 chr20 4721316 PRNT OpenSea 0.017 0.002 5.44E18 cg12318914 chr4 17387235   OpenSea − 0.026 0.003 1.28E−13
cg08637691 chr9 134989631   OpenSea 0.021 0.002 5.48E18 cg11102031 chr6 148060358   OpenSea 0.015 0.002 1.76E13
cg02669012 chr10 58382013   OpenSea − 0.019 0.002 6.34E−18 cg25181130 chr17 30651431 RHBDL3 OpenSea 0.020 0.003 2.77E13
cg24501701 chr12 63544040 AVPR1A Island 0.013 0.001 9.79E18 cg09461021 chr22 20969574   OpenSea 0.018 0.002 3.11E13
cg15628888 chr15 72612209 CELF6 Island 0.028 0.003 1.08E17 cg07504615 chr3 14832729   OpenSea − 0.013 0.002 4.99E−13
cg07323488 chr3 168185313 EGFEM1P OpenSea − 0.021 0.002 2.30E−17 cg09445550 chr20 5106966 PCNA N_Shore 0.015 0.002 6.90E13
cg17891166 chr7 73441989 ELN OpenSea 0.014 0.002 2.87E17 cg06506328 chr10 69373205 CTNNA3 OpenSea 0.021 0.003 7.25E13
cg04978384 chr15 58358310 ALDH1A2 Island 0.027 0.003 4.62E−17 cg08176240 chr15 31489071   OpenSea 0.016 0.002 7.42E13
cg03947688 chr5 79866382 ANKRD34B Island 0.015 0.002 4.68E−17 cg18805621 chr4 10583796 CLNK OpenSea 0.018 0.003 1.16E12
cg12318914 chr4 17387235   OpenSea − 0.026 0.003 5.64E−17 cg00067981 chr21 27254444 APP OpenSea 0.011 0.002 1.44E12
cg22558303 chr13 96705786 UGGT2 Island 0.038 0.005 6.53E17 cg17554862 chr2 201991544 CFLAR OpenSea 0.013 0.002 2.17E12
cg00394316 chr7 22539822 MGC87042 Island 0.034 0.004 6.73E17 cg21323642 chr22 31709724   OpenSea − 0.011 0.002 2.30E−12
cg00101260 chr17 53426657   OpenSea 0.013 0.002 6.81E17 cg16476710 chr14 37304393 SLC25A21 OpenSea 0.026 0.004 2.40E12
cg18284157 chr22 37099802 CACNG2 S_Shore 0.017 0.002 8.96E17 cg04978384 chr15 58358310 ALDH1A2 Island 0.025 0.004 2.65E−12
cg09849302 chr21 38378433 RIPPLY3 Island 0.020 0.002 1.73E16 cg16381169 chr21 16031542   OpenSea 0.014 0.002 2.78E12
cg26153045 chr7 73441834 ELN OpenSea 0.015 0.002 2.17E16 cg20193323 chr6 7276020   OpenSea 0.027 0.004 3.21E12
cg26081188 chr11 19726873 NAV2 OpenSea − 0.017 0.002 2.42E−16 cg16169166 chr3 14303148   OpenSea 0.021 0.003 3.36E12
cg21328810 chr19 50829227 KCNC3 Island 0.013 0.002 2.59E16 cg10934519 chr3 69720954   OpenSea 0.015 0.002 3.99E12
cg25258740 chr12 75603230 KCNC2 Island 0.032 0.004 2.60E16 cg17365308 chr12 126536415   OpenSea 0.020 0.003 5.40E12
cg07522171 chr7 28218686 JAZF1-AS1 N_Shore 0.015 0.002 2.92E16 cg26772387 chr15 91846753   OpenSea 0.013 0.002 5.96E12
cg20168635 chr15 83916827   OpenSea 0.017 0.002 4.28E16 cg26928911 chr1 22968992 C1QC OpenSea − 0.016 0.002 7.05E−12
cg25045526 chr7 121944506 FEZF1 Island 0.019 0.002 4.84E16 cg09579833 chr3 49849871 UBA7 OpenSea 0.013 0.002 7.37E12
cg26079664 chr3 51740956 GRM2 Island 0.028 0.003 5.18E16 cg07132386 chr2 207139218 ZDBF2 N_Shore 0.018 0.003 8.17E−12
cg06210197 chr8 24771256 NEFM Island 0.023 0.003 5.29E−16 cg01156568 chr6 87849235   OpenSea − 0.022 0.003 1.15E−11
  1. IlmnID: CpG probe identification number, SE: standard error
  2. *Overlapping age-associated differentially methylated CpG positions between African Americans and whites are highlighted in bold