DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures

Table 1 Summary of the main findings described in this study

Tissue	Variables measured	Methods	Groups comparison	Effect
Neocortex	DNMT1	WB	All TLE groups vs CTRL	↑
Neocortex	DNMT3a1 DNMT3a1	WB, qRT-PCR	All TLE groups vs CTRL	↑
Neocortex	5-mC	IHC	All TLE groups vs CTRL	↑
Hippocampus	DNMT1	WB	HS⁻ vs CTRL	↑
Hippocampus	DNMT3a2	qRT-PCR, ISH	All TLE groups vs CTRL	↓
Hippocampus	DNMT3a2	WB	HS⁺FS⁺ vs CTRL HS⁺FS⁺ vs HS⁻ HS⁺FS⁺ vs HS⁺	↓
Hippocampus	5-mC, 5hmC	IHC	All TLE groups vs CTRL	↓
Hippocampus	DNMT3a1 DNMT3a1	WB, qRT-PCR	HS⁺FS⁺ vs CTRL HS⁺FS⁺ vs HS⁻ HS⁺FS⁺ vs HS⁺	↓

WB Western blot, TLE temporal lobe epilepsy, CTRL control, qRT-PCR quantitative reverse transcription polymerase chain reaction, IHC immunohistochemistry, ISH in situ hybridization, FS febrile seizures, HS hippocampal sclerosis

ISSN: 1868-7083