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Table 1 Summary of the main findings described in this study

From: DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures

Tissue Variables measured Methods Groups comparison Effect
Neocortex DNMT1 WB All TLE groups vs CTRL
Neocortex DNMT3a1 DNMT3a1 WB, qRT-PCR All TLE groups vs CTRL
Neocortex 5-mC IHC All TLE groups vs CTRL
Hippocampus DNMT1 WB HS vs CTRL
Hippocampus DNMT3a2 qRT-PCR, ISH All TLE groups vs CTRL
Hippocampus DNMT3a2 WB HS+FS+ vs CTRL HS+FS+ vs HS HS+FS+ vs HS+
Hippocampus 5-mC, 5hmC IHC All TLE groups vs CTRL
Hippocampus DNMT3a1 DNMT3a1 WB, qRT-PCR HS+FS+ vs CTRL HS+FS+ vs HS HS+FS+ vs HS+
  1. WB Western blot, TLE temporal lobe epilepsy, CTRL control, qRT-PCR quantitative reverse transcription polymerase chain reaction, IHC immunohistochemistry, ISH in situ hybridization, FS febrile seizures, HS hippocampal sclerosis