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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance

Fig. 6

SEPT9 affects irradiation sensitivity by regulating macrophage polarization. a Representative images of immunohistochemical staining of CD206 in cervical cancer and in normal cervical epithelium. Forty-four of the 60 patients had CD206 positive in cancer tissues. b Immunofluorescence of CD206 after treatment of LPS (100 ng/ml)+IFN-γ (20 ng/ml), IL4 (20 ng/ml)+IL-10 (20 ng/ml), CM-NC-4Gy, CM-SEPT9-4Gy for 48 h. c Western blotting of CD206, Arg1, and INOS. d The relative mRNA expression of CD206, CD163, Arg1, and INOS by using qRT-PCR

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