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Fig. 4 | Clinical Epigenetics

Fig. 4

From: Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance

Fig. 4

ag SEPT9 increases irradiation resistance in vitro and in vivo. a, b Cell viability after different doses of irradiation treatment was increased by HeLa transfected siSEPT9 and decreased by CaSki transfected SEPT9-LV. c, d γH2AX expression and subcellular localization were detected using immunofluorescence in HeLa cells transfected with SEPT9 overexpression. e HeLa cells with or without SEPT9 overexpression were subcutaneously inoculated into nude mice. Each group contained 5 mice. f Growth curves of tumors in control/SEPT9 overexpression group and after 30 days the mice were given irradiation total 15Gy. g The tumor ratio after and before radiation treatment

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