Fig. 4

a–g SEPT9 increases irradiation resistance in vitro and in vivo. a, b Cell viability after different doses of irradiation treatment was increased by HeLa transfected siSEPT9 and decreased by CaSki transfected SEPT9-LV. c, d γH2AX expression and subcellular localization were detected using immunofluorescence in HeLa cells transfected with SEPT9 overexpression. e HeLa cells with or without SEPT9 overexpression were subcutaneously inoculated into nude mice. Each group contained 5 mice. f Growth curves of tumors in control/SEPT9 overexpression group and after 30 days the mice were given irradiation total 15Gy. g The tumor ratio after and before radiation treatment