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Fig. 2 | Clinical Epigenetics

Fig. 2

From: “Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a review

Fig. 2

ENS development. In mice, ENS development has been studied thoroughly. Vagal NCCs migrate in a rostral to caudal direction eventually colonizing the entire length of the gut. Vagal NCCs invade the anterior foregut and continue along the midgut and hindgut. On embryonic day 11.5, there is a small wave of NCCs that cross over from the foregut to the hindgut. There is also a minor contribution of anterior trunk NCCs to the foregut and of sacral NCCs to the hindgut

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