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Table 3 Sensitivity, specificity, positive and negative predictive values (PPV and NPV) of the DNA methylation biomarkers (RARB, RASSF1 and GSTP1) together with Partin nomogram values for predicting upstaging

From: Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging

Parameter Sensitivity, % Specificity, % PPV, % NPV, %
Voided urine (N = 188)
 Partin 53.3 77.0 37.1 86.6
RARB, RASSF1, GSTP1+Partin 75.0 60.3 32.5 90.5
RASSF1, GSTP1+Partin 43.2 91.3 55.7 86.3
Catheterized urine (N = 326)
 Partin 56.5 79.8 41.6 82.4
RARB, RASSF1, GSTP1+Partin 61.0 79.8 43.5 88.9
RASSF1, GSTP1+Partin 59.3 80.8 44.0 88.6