Table 3 Sensitivity, specificity, positive and negative predictive values (PPV and NPV) of the DNA methylation biomarkers (RARB, RASSF1 and GSTP1) together with Partin nomogram values for predicting upstaging
From: Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging
Parameter | Sensitivity, % | Specificity, % | PPV, % | NPV, % |
|---|---|---|---|---|
Voided urine (N = 188) | ||||
Partin | 53.3 | 77.0 | 37.1 | 86.6 |
RARB, RASSF1, GSTP1+Partin | 75.0 | 60.3 | 32.5 | 90.5 |
RASSF1, GSTP1+Partin | 43.2 | 91.3 | 55.7 | 86.3 |
Catheterized urine (N = 326) | ||||
Partin | 56.5 | 79.8 | 41.6 | 82.4 |
RARB, RASSF1, GSTP1+Partin | 61.0 | 79.8 | 43.5 | 88.9 |
RASSF1, GSTP1+Partin | 59.3 | 80.8 | 44.0 | 88.6 |