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Table 1 ROC curve values of particular gene methylation alone and combined with PSA as biomarkers of upstaging, upgrading, and risk increase

From: Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging

Gene Voided urine (N = 188) Catheterized urine (N = 326)
Gene methylation only Gene methylation + PSA Gene methylation only Gene methylation + PSA
AUC P value AUC P value AUC P value AUC P value
Upstaging
RARB 0.551 0.330 0.596 0.053 0.554 0.154 0.626 0.002
RASSF1 0.586 0.106 0.608 0.029 0.540 0.313 0.632 0.001
GSTP1 0.575 0.062 0.608 0.033 0.533 0.174 0.627 0.018
Upgrading
RARB 0.508 0.862 0.532 0.470 0.521 0.600 0.682 < 0.001
RASSF1 0.581 0.074 0.600 0.025 0.571 0.082 0.692 < 0.001
GSTP1 0.503 0.919 0.517 0.704 0.550 0.065 0.715 < 0.001
Risk increase
RARB 0.558 0.194 0.518 0.692 0.510 0.816 0.589 0.045
RASSF1 0.538 0.434 0.537 0.426 0.523 0.599 0.597 0.025
GSTP1 0.539 0.189 0.521 0.634 0.557 0.047 0.623 0.004
  1. Significant P values are in bold