Clinical Epigenetics

Table 1 ROC curve values of particular gene methylation alone and combined with PSA as biomarkers of upstaging, upgrading, and risk increase

From: Urinary DNA methylation biomarkers for prediction of prostate cancer upgrading and upstaging

Gene	Voided urine (N = 188)				Catheterized urine (N = 326)
	Gene methylation only		Gene methylation + PSA		Gene methylation only		Gene methylation + PSA
	AUC	P value	AUC	P value	AUC	P value	AUC	P value
Upstaging
RARB	0.551	0.330	0.596	0.053	0.554	0.154	0.626	0.002
RASSF1	0.586	0.106	0.608	0.029	0.540	0.313	0.632	0.001
GSTP1	0.575	0.062	0.608	0.033	0.533	0.174	0.627	0.018
Upgrading
RARB	0.508	0.862	0.532	0.470	0.521	0.600	0.682	< 0.001
RASSF1	0.581	0.074	0.600	0.025	0.571	0.082	0.692	< 0.001
GSTP1	0.503	0.919	0.517	0.704	0.550	0.065	0.715	< 0.001
Risk increase
RARB	0.558	0.194	0.518	0.692	0.510	0.816	0.589	0.045
RASSF1	0.538	0.434	0.537	0.426	0.523	0.599	0.597	0.025
GSTP1	0.539	0.189	0.521	0.634	0.557	0.047	0.623	0.004

Significant P values are in bold

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ISSN: 1868-7083

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