Table 3 Summary statistics from discovery and replication from gene-based analysis for serum tIgE levels, not adjusted for Eos and Neu fractions. One significant CpG from the discovery stage replicated (based on a Bonferroni correction for 9 tests) with an additional CpG suggestive of replication
From: Replicated methylation changes associated with eczema herpeticum and allergic response
Discovery data set | Replication data set | |||||||
|---|---|---|---|---|---|---|---|---|
ID | CHR | POS (hg19) | GENE | Diff_IgE_cases | Pval_IgE_cases | qval_IgE_cases | Diff_IgE_cases | Pval_IgE_cases |
cg26787239 | 5 | 132008525 | IL4 | − 0.1073 | 0.0002 | 0.0042 | − 0.07098 | 0.0045 |
cg15329179 | 5 | 131993728 | IL13 | − 0.08296 | 0.00033 | 0.0042 | − 0.0628 | 0.01595 |
cg06641959 | 16 | 27325254 | IL4R | 0.05223 | 0.00251 | 0.0163 | − 0.0035 | 0.8569 |
cg06967316 | 5 | 131993853 | IL13 | − 0.04903 | 0.00192 | 0.0163 | − 0.0096 | 0.6556 |
cg14523284 | 5 | 131993614 | IL13 | − 0.06025 | 0.00335 | 0.0174 | 0.0049 | 0.7816 |
cg23943829 | 5 | 132009111 | IL4 | − 0.0549 | 0.0055 | 0.0237 | − 0.0258 | 0.2095 |