Skip to main content

Advertisement

Table 3 Summary statistics from discovery and replication from gene-based analysis for serum tIgE levels, not adjusted for Eos and Neu fractions. One significant CpG from the discovery stage replicated (based on a Bonferroni correction for 9 tests) with an additional CpG suggestive of replication

From: Replicated methylation changes associated with eczema herpeticum and allergic response

     Discovery data set Replication data set
ID CHR POS (hg19) GENE Diff_IgE_cases Pval_IgE_cases qval_IgE_cases Diff_IgE_cases Pval_IgE_cases
cg26787239 5 132008525 IL4 − 0.1073 0.0002 0.0042 − 0.07098 0.0045
cg15329179 5 131993728 IL13 − 0.08296 0.00033 0.0042 − 0.0628 0.01595
cg06641959 16 27325254 IL4R 0.05223 0.00251 0.0163 − 0.0035 0.8569
cg06967316 5 131993853 IL13 − 0.04903 0.00192 0.0163 − 0.0096 0.6556
cg14523284 5 131993614 IL13 − 0.06025 0.00335 0.0174 0.0049 0.7816
cg23943829 5 132009111 IL4 − 0.0549 0.0055 0.0237 − 0.0258 0.2095
  1. Diff_IgE_cases difference in methylation values (M-value scale), Pval_IgE_cases p value obtained from differential methylation analysis for serum tIgE levels, qval_IgE_cases FDR corrected q values calculated on set of CpGs in IL4 and IL13 genes