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Table 2 Summary statistics from discovery and replication from gene-based analysis comparing ADEH+ individuals to non-atopic healthy controls, adjusted for Eos and Neu fractions. Both significant CpGs from the discovery stage were suggestive for replication (based on a Bonferroni correction for 9 tests)

From: Replicated methylation changes associated with eczema herpeticum and allergic response

    

Discovery data set

Replication data set

ID

CHR

POS

(hg19)

GENE

Diff_EHNA

Pval_EHNA

qval_EHNA

Diff_EHNA

Pval_EHNA

cg23943829

5

132009111

IL4

− 0.1425

0.0002

0.0287

− 0.0996

0.0509

cg04303330

5

131992430

IL13

− 0.1516

0.0007

0.044

− 0.1226

0.0941

  1. Diff_EHNA difference in methylation values (M-value scale) between ADEH+ and healthy control group, Pval_EHNA p value obtained from ADEH+ vs healthy control differential methylation analysis, qval_EHNA FDR corrected q values calculated on a set of CpGs in our genes of interest