Fig. 4
From: Histone methyltransferase SMYD2: ubiquitous regulator of disease
The nonhistone substrates of SMYD2 involved in cancer and other disease. Several nonhistone proteins are methylated by SMYD2 during cancer formation, including p53, RB, PTEN, ERα, PARP1, ALK, MAPKAPK3, and HSP90AB1. SMYD2 methylates and activates p65 and STAT3 to regulate autosomal dominant polycystic kidney disease. BMPR2 methylated by SMYD2 to activate SMAD1/5 signaling. Methylation on substrates always cross-talks with other posttranslational modifications, especially phosphorylation, to affect signaling pathways and target genes related to cancer and other disease