Fig. 8

DNA methylation profile derived from the combined discovery and replication datasets of CPTs after applying CPC specific DNA methylation signature (59 differentially methylated CpG sites), Kaplan–Meier plots showing overall survival by methylation subgroups or by histological diagnosis along with tables showing frequency of death event and histograms showing frequency of recurrence events within each of the DNA methylation signature derived clusters as well as for each of the histologically defined CPTs. a DNA methylation clusters of the 95 CPT samples (combined datasets of 34 samples used in discovery cohort and 61 samples from replication cohort) defined by applying CPC-specific DNA methylation signature. Hierarchical clustering was done using Euclidean metric. High methylation = yellow; low methylation = blue; diagnosis: cpc = red, acpp = pink, cpp = turquoise; age: A = adults, P = pediatric cases, U = unknown. Kaplan–Meier curves depicting overall survival (OS) estimates of patients with CPT by methylation subgroups (b) or by histological diagnosis (d). Statistical values were obtained with the log-rank chi-square = 11.8 (df = 1), p value 0.0008, when comparing patients grouped by methylation clusters and with the log-rank chi-square = 0.003495 (df = 2), p value 0.9529, when comparing patients grouped by diagnosis. Histograms showing frequency of recurrence event in each of the clusters derived from DNA methylation signature (c) of 95 CPT samples or for each of the histologically defined CPTs (e)