Fig. 6

Heatmap of brain tumor DNA methylation datasets from GEO and TCGA databases with CPC-specific DNA methylation signature (59 differentially methylated CpG sites). Comparison of CPC-specific DNA methylation signature to other brain tumors. Brain tumor data were derived from GEO database under accession number GSE50022—for diffuse intrinsic pontine glioma (DIPG) (n = 28), GSE44684—from pilocytic astrocytoma (PA) n = 61-PA and n = 6 normal cerebellum (CTRL)), and GSE52556—from embryonal tumors with multilayered rosettes (ETMR) (n = 12), primitive neuroectodermal tumors (PNET) (n = 28), normal brain (CTRL) (n = 34), and TCGA-glioma (n = 24) and low grade glioma (LGG) (n = 30) from TCGA. CPTs diagnosis: cpc = red, acpp = pink, cpp = turquoise. Hierarchical clustering was done using Euclidean metric. High methylation = yellow; low methylation = blue