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Fig. 1 | Clinical Epigenetics

Fig. 1

From: DNA methylation signature is prognostic of choroid plexus tumor aggressiveness

Fig. 1

Two-way clustering performed on 34 CPT samples using Pearson’s correlation and average linkage (a) and PCA (b, c) using the top 3361 most differentially methylated CpGs (p < 0.05 after FDR correction and at least 30% methylation difference) shows segregation between majority of carcinomas (cpc) and papillomas (cpp and acpp). In addition, we observed segregation within the CPC group based on TP53 status. Homozygous TP53-mut (mutant) = violet bar (a) and outlined in pink box (a, b); heterozygous TP53-mut = orange bar (a) and outlined in blue box (a, b); TP53-wt (wild type) = green bar (a) and green dots (b); diagnosis: acpp = pink, cpc = red, and cpp = turquoise (ac). The numbers 1, 2, and 3 in PCA plots represent component 1, component 2, and component 3

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