Table 5 Top 20 IPA Canonical Pathways by time point for control versus pool sequential/simultaneous
From: Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation
Ingenuity canonical pathways | −log (p value) | Ratio |
|---|---|---|
3 months | ||
 GDP-l-fucose Biosynthesis I (from GDP-d-mannose) | 1.89 | 0.500 |
 Methylmalonyl pathway | 1.59 | 0.250 |
 2-Oxobutanoate degradation I | 1.49 | 0.200 |
 PI3K/AKT signaling | 1.33 | 0.024 |
 GM-CSF signaling | 1.08 | 0.027 |
 Colanic acid building blocks biosynthesis | 1.06 | 0.071 |
 Wnt/β-catenin signaling | 1.01 | 0.018 |
 Mitochondrial l-carnitine shuttle pathway | 0.98 | 0.059 |
 Bladder cancer signaling | 0.96 | 0.023 |
 GADD45 signaling | 0.93 | 0.053 |
 Acute myeloid leukemia signaling | 0.92 | 0.022 |
 Inflammasome pathway | 0.91 | 0.050 |
 Pyrimidine deoxyribonucleotides de novo biosynthesis I | 0.85 | 0.044 |
 Estrogen-mediated S-phase entry | 0.81 | 0.039 |
 Sonic hedgehog signaling | 0.76 | 0.035 |
 Sperm motility | 0.73 | 0.017 |
 LXR/RXR activation | 0.73 | 0.017 |
 FXR/RXR activation | 0.71 | 0.016 |
 Circadian rhythm signaling | 0.70 | 0.029 |
9 months | ||
 GDP-l-fucose biosynthesis I (from GDP-d-mannose) | 1.65 | 0.500 |
 Estrogen-mediated S-phase entry | 1.47 | 0.077 |
 Glioblastoma multiforme signaling | 1.45 | 0.031 |
 p53 signaling | 1.44 | 0.036 |
 Methylmalonyl pathway | 1.36 | 0.250 |
 PI3K/AKT signaling | 1.30 | 0.033 |
 2-Oxobutanoate degradation I | 1.26 | 0.200 |
 Cell cycle regulation by BTG family proteins | 1.19 | 0.054 |
 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde | 1.18 | 0.167 |
 nNOS signaling in skeletal muscle cells | 1.13 | 0.050 |
 Bladder cancer signaling | 1.13 | 0.035 |
 Phosphatidylcholine biosynthesis I | 1.12 | 0.143 |
 tRNA splicing | 1.11 | 0.049 |
 Ovarian cancer signaling | 1.11 | 0.028 |
 Role of p14/p19ARF in tumor suppression | 1.09 | 0.048 |
 Phosphatidylethanolamine biosynthesis II | 1.06 | 0.125 |
 Gustation pathway | 1.05 | 0.027 |
 GABA receptor signaling | 1.05 | 0.032 |
 Role of Oct4 in mammalian embryonic stem cell pluripotency | 1.04 | 0.044 |