Skip to main content

Advertisement

Table 5 Top 20 IPA Canonical Pathways by time point for control versus pool sequential/simultaneous

From: Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation

Ingenuity canonical pathways −log (p value) Ratio
3 months
 GDP-l-fucose Biosynthesis I (from GDP-d-mannose) 1.89 0.500
 Methylmalonyl pathway 1.59 0.250
 2-Oxobutanoate degradation I 1.49 0.200
 PI3K/AKT signaling 1.33 0.024
 GM-CSF signaling 1.08 0.027
 Colanic acid building blocks biosynthesis 1.06 0.071
 Wnt/β-catenin signaling 1.01 0.018
 Mitochondrial l-carnitine shuttle pathway 0.98 0.059
 Bladder cancer signaling 0.96 0.023
 GADD45 signaling 0.93 0.053
 Acute myeloid leukemia signaling 0.92 0.022
 Inflammasome pathway 0.91 0.050
 Pyrimidine deoxyribonucleotides de novo biosynthesis I 0.85 0.044
 Estrogen-mediated S-phase entry 0.81 0.039
 Sonic hedgehog signaling 0.76 0.035
 Sperm motility 0.73 0.017
 LXR/RXR activation 0.73 0.017
 FXR/RXR activation 0.71 0.016
 Circadian rhythm signaling 0.70 0.029
9 months
 GDP-l-fucose biosynthesis I (from GDP-d-mannose) 1.65 0.500
 Estrogen-mediated S-phase entry 1.47 0.077
 Glioblastoma multiforme signaling 1.45 0.031
 p53 signaling 1.44 0.036
 Methylmalonyl pathway 1.36 0.250
 PI3K/AKT signaling 1.30 0.033
 2-Oxobutanoate degradation I 1.26 0.200
 Cell cycle regulation by BTG family proteins 1.19 0.054
 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 1.18 0.167
 nNOS signaling in skeletal muscle cells 1.13 0.050
 Bladder cancer signaling 1.13 0.035
 Phosphatidylcholine biosynthesis I 1.12 0.143
 tRNA splicing 1.11 0.049
 Ovarian cancer signaling 1.11 0.028
 Role of p14/p19ARF in tumor suppression 1.09 0.048
 Phosphatidylethanolamine biosynthesis II 1.06 0.125
 Gustation pathway 1.05 0.027
 GABA receptor signaling 1.05 0.032
 Role of Oct4 in mammalian embryonic stem cell pluripotency 1.04 0.044