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Table 3 Top 10 differentially methylation regions for 9-month control vs. pooled sequential/simultaneous

From: Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation

Region coordinates Genes in region Gene function [42] # CpGs FDR Stouffer β (max) β (mean)
chr8:51306070–51306693 SNTG1 Mediates dystrophin binding. Associated with idiopathic scoliosis [49]. 3 2.49E− 09 0.0904 0.2066 0.1012
chr3:150265617–150265620 SERP1 Protein folding and metabolism. Inhibition can downregulate the Wnt/β-catenin pathway in keratinocytes [70]. 2 4.96E− 06 0.1754 0.0351 0.0327
chr3:44636619–44636844 ZNF197 Transcription factor with potential role in skeletal muscle energy metabolism following exercise [71]. 2 0.0008 0.3556 0.0465 0.0267
chr22:49875144–49875295 C22orf34 Chromosome 22 Open Reading Frame 34, uncharacterized protein. 2 0.0040 0.3980 − 0.0775 − 0.0575
chr16:1477870–1478718 C16orf91 Chromosome 16 Open Reading Frame 91, uncharacterized protein. 3 0.0001 0.4290 − 0.0667 − 0.0434
chr19:7813422–7813963 EXOSC3P2 Pseudogene, unknown function. 3 3.81E− 06 0.4426 − 0.0800 − 0.0468
chr13:101173617–101174420 PCCA Subunit of mitochondrial enzyme critical to energy metabolism [72]. 8 4.01E− 11 0.4572 − 0.0929 − 0.0537
chr11:1903176–1903333 LSP1 Expressed in immune system cells and may regulate motility and transendothelial migration. Potential marker of hepatocellular carcinoma risk [73]. 2 0.0047 0.4611 − 0.0586 − 0.0486
chr4:185369135–185370076 IRF2 Competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta. Decreased expression associated with angiogenesis and inflammation [43, 44]. 3 0.0030 0.4752 − 0.1271 − 0.0100
chr4:175241684–175241753 CEP44 Centrosomal protein 2 0.0071 0.4980 − 0.1368 − 0.0847
chr17:72915897–72916509 USH1G Auditory and visual function development [50]. 3 0.0009 0.5005 − 0.0636 − 0.0595