Skip to main content

Table 2. Top 10 differentially methylation regions for 3-month control vs. pooled sequential/simultaneous

From: Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation

Region coordinates

Genes in region

Gene function [42]

# CpGs

FDR

Stouffer

β (max)

β (mean)

chr1:228756711–228756714

DUSP5P1

Pseudogene for MAPK phosphatase, proposed as a tumor suppressor in hematopoietic cancers [45, 46].

2

0.0036

0.7466

− 0.1183

− 0.1183

chr19:37463254–37463280

ZNF568

Role in transcriptional repression during embryonic development. Potential role in sessile serrated colon polyps [48].

2

0.0013

0.7671

0.0787

0.0549

chr20:58662458–58662959

Unknown

N/A

2

0.0029

0.7729

− 0.0878

− 0.0791

chr3:119499749–119500059

NR1I2

Transcription factor regulating detoxification and xenobiotic metabolism [65].

2

0.0004

0.8361

0.0982

0.0625

chr1:229764652–229764706

URB2

Ribosomal biosynthesis

2

0.0059

0.8873

0.0622

0.0351

chr2:105990524–105991411

FHL2

Assembly of extracellular membranes and used in models estimating epigenetic aging [66,67,68].

3

0.0013

0.8891

0.0539

0.0448

chr5:488398–488527

SLC4A4

Sodium biocarbonate cotransporter. Regulation of intracellular pH and renal tubular function [69].

2

0.0141

0.8900

0.0660

0.0493

chr3:46599958–46600244

Unknown

N/A

2

0.0147

0.8921

0.0738

0.0568

chr1:187445635–187445942

LINC01037

Long intergenic non-protein coding RNA 1037

2

0.0233

0.8955

− 0.0617

− 0.0354

chr4:185369135–185370076

IRF2

Competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta. Decreased expression is associated with angiogenesis and inflammation [43, 44].

3

0.0029

0.8977

− 0.1266

− 0.1005