From: Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation
Region coordinates | Genes in region | Gene function [42] | # CpGs | FDR | Stouffer | β (max) | β (mean) |
---|---|---|---|---|---|---|---|
chr1:228756711–228756714 | DUSP5P1 | Pseudogene for MAPK phosphatase, proposed as a tumor suppressor in hematopoietic cancers [45, 46]. | 2 | 0.0036 | 0.7466 | − 0.1183 | − 0.1183 |
chr19:37463254–37463280 | ZNF568 | Role in transcriptional repression during embryonic development. Potential role in sessile serrated colon polyps [48]. | 2 | 0.0013 | 0.7671 | 0.0787 | 0.0549 |
chr20:58662458–58662959 | Unknown | N/A | 2 | 0.0029 | 0.7729 | − 0.0878 | − 0.0791 |
chr3:119499749–119500059 | NR1I2 | Transcription factor regulating detoxification and xenobiotic metabolism [65]. | 2 | 0.0004 | 0.8361 | 0.0982 | 0.0625 |
chr1:229764652–229764706 | URB2 | Ribosomal biosynthesis | 2 | 0.0059 | 0.8873 | 0.0622 | 0.0351 |
chr2:105990524–105991411 | FHL2 | Assembly of extracellular membranes and used in models estimating epigenetic aging [66,67,68]. | 3 | 0.0013 | 0.8891 | 0.0539 | 0.0448 |
chr5:488398–488527 | SLC4A4 | Sodium biocarbonate cotransporter. Regulation of intracellular pH and renal tubular function [69]. | 2 | 0.0141 | 0.8900 | 0.0660 | 0.0493 |
chr3:46599958–46600244 | Unknown | N/A | 2 | 0.0147 | 0.8921 | 0.0738 | 0.0568 |
chr1:187445635–187445942 | LINC01037 | Long intergenic non-protein coding RNA 1037 | 2 | 0.0233 | 0.8955 | − 0.0617 | − 0.0354 |
chr4:185369135–185370076 | IRF2 | Competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta. Decreased expression is associated with angiogenesis and inflammation [43, 44]. | 3 | 0.0029 | 0.8977 | − 0.1266 | − 0.1005 |