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Table 2. Top 10 differentially methylation regions for 3-month control vs. pooled sequential/simultaneous

From: Impact of a diet and activity health promotion intervention on regional patterns of DNA methylation

Region coordinates Genes in region Gene function [42] # CpGs FDR Stouffer β (max) β (mean)
chr1:228756711–228756714 DUSP5P1 Pseudogene for MAPK phosphatase, proposed as a tumor suppressor in hematopoietic cancers [45, 46]. 2 0.0036 0.7466 − 0.1183 − 0.1183
chr19:37463254–37463280 ZNF568 Role in transcriptional repression during embryonic development. Potential role in sessile serrated colon polyps [48]. 2 0.0013 0.7671 0.0787 0.0549
chr20:58662458–58662959 Unknown N/A 2 0.0029 0.7729 − 0.0878 − 0.0791
chr3:119499749–119500059 NR1I2 Transcription factor regulating detoxification and xenobiotic metabolism [65]. 2 0.0004 0.8361 0.0982 0.0625
chr1:229764652–229764706 URB2 Ribosomal biosynthesis 2 0.0059 0.8873 0.0622 0.0351
chr2:105990524–105991411 FHL2 Assembly of extracellular membranes and used in models estimating epigenetic aging [66,67,68]. 3 0.0013 0.8891 0.0539 0.0448
chr5:488398–488527 SLC4A4 Sodium biocarbonate cotransporter. Regulation of intracellular pH and renal tubular function [69]. 2 0.0141 0.8900 0.0660 0.0493
chr3:46599958–46600244 Unknown N/A 2 0.0147 0.8921 0.0738 0.0568
chr1:187445635–187445942 LINC01037 Long intergenic non-protein coding RNA 1037 2 0.0233 0.8955 − 0.0617 − 0.0354
chr4:185369135–185370076 IRF2 Competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta. Decreased expression is associated with angiogenesis and inflammation [43, 44]. 3 0.0029 0.8977 − 0.1266 − 0.1005