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Table 4 Module-risk factor relationships (current and cumulative) after adjustment for covariates

From: DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure

 

Brown

Blue

Risk factor

Current

Cumulative

Current

Cumulative

BMI

0.036 (4.3e −06)

0.051 (2.3e −10)

0.026 (0.0061)

0.019 (0.051)

Glu

0.021 (0.011)

0.027 (0.0011)

− 0.00065 (0.95)

− 0.0045 (0.66)

hsCRP

0.021 (0.0077)

0.039 (1e −06)

0.025 (0.011)

0.014 (0.15)

TG

0.018 (0.02)

0.042 (5e −07)

0.021 (0.03)

0.015 (0.14)

HDL

− 0.021 (0.015)

− 0.017 (0.056)

− 0.038 (0.00031)

− 0.03 (0.0067)

LDL

− 0.012 (0.13)

0.0089 (0.29)

− 0.00072 (0.94)

0.027 (0.0088)

Chol

− 0.014 (0.11)

0.019 (0.021)

− 0.013 (0.2)

0.012 (0.24)

SBP

0.012 (0.15)

0.024 (0.0084)

− 0.011 (0.27)

− 0.0015 (0.89)

  1. Regression results are presented as beta (p value). Models are adjusted for age, sex, smoking status and pack-years, estimated cell counts, study center, and 7 control probe principal components