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Table 1 Population description

From: DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure

  FHS WHI
Sample size 2587 2023
% female 55% 100%
Age at blood draw 66 (60–73) 65 (59–70)
Mixed ancestry No Yes
Body mass index (BMI) 27.7 (24.5–31) 29.1 (25.5–33.3)
% smoke currently 9% 10%
Smoking pack-years 0 (0–0) 0 (0–12.5)
No. of prior CVD events 331 0
No. of incident CVD events 305 1009
Total cholesterol (Chol; mg/dL) 185 (161–211) 230 (206–259)
LDL-cholesterol (LDL; mg/dL) 104 (84–126) 150 (126–175)
HDL-cholesterol (HDL; mg/dL) 55 (44–68) 51 (43–60)
Triglycerides (TG; mg/dL) 102 (74–142) 127 (92–177)
Fasting glucose (Glu; mg/dL) 101 (94–110) 96 (88.6–108)
High-sensitivity C-reactive protein (hsCRP; mg/dL) 1.5 (0.8–3.2) 3.1 (1.4–6.5)
Systolic blood pressure (SBP; mmHg) 127 (116–139) 131 (120–143)
  1. Continuous values shown as median (interquartile range). Ninety-two subjects experienced both prior and incident CVD events