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Table 1 Population description

From: DNA methylation modules associate with incident cardiovascular disease and cumulative risk factor exposure

 

FHS

WHI

Sample size

2587

2023

% female

55%

100%

Age at blood draw

66 (60–73)

65 (59–70)

Mixed ancestry

No

Yes

Body mass index (BMI)

27.7 (24.5–31)

29.1 (25.5–33.3)

% smoke currently

9%

10%

Smoking pack-years

0 (0–0)

0 (0–12.5)

No. of prior CVD events

331

0

No. of incident CVD events

305

1009

Total cholesterol (Chol; mg/dL)

185 (161–211)

230 (206–259)

LDL-cholesterol (LDL; mg/dL)

104 (84–126)

150 (126–175)

HDL-cholesterol (HDL; mg/dL)

55 (44–68)

51 (43–60)

Triglycerides (TG; mg/dL)

102 (74–142)

127 (92–177)

Fasting glucose (Glu; mg/dL)

101 (94–110)

96 (88.6–108)

High-sensitivity C-reactive protein (hsCRP; mg/dL)

1.5 (0.8–3.2)

3.1 (1.4–6.5)

Systolic blood pressure (SBP; mmHg)

127 (116–139)

131 (120–143)

  1. Continuous values shown as median (interquartile range). Ninety-two subjects experienced both prior and incident CVD events