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Table 2 Association of the coefficient score with disease-specific survival in the study cohort and the validation cohort

From: A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival

Patient groups

Subgroups

Tertile groups (cutoff points)

Study cohort

Validation cohort

N

Deaths (%)

HR (95% CI)a

p value of trend

N

Deaths (%)

HR (95% CI)a

p value of trend

All patients

 

Tertile 3

195

36 (18)

Ref.

 

124

25 (20)

Ref.

 

Tertile 2 (− 4.32247)

188

31 (16)

1.31 (0.80–2.15)

 

89

22 (25)

1.66 (0.91–3.05)

 

Tertile 1 (− 3.92950)

185

69 (37)

3.16 (2.08–4.80)

< 0.0001

95

35 (37)

2.75 (1.56–4.85)

0.0004

Microsatellite instability

MSS

Tertile 3

175

35 (20)

Ref.

 

114

25 (22)

Ref.

 

Tertile 2 (− 4.32247)

161

29 (18)

1.31 (0.79–2.17)

 

79

21 (27)

1.63 (0.88–3.01)

 

Tertile 1 (− 3.92950)

167

66 (40)

3.11 (2.04–4.76)

< 0.0001

89

33 (37)

2.65 (1.49–4.72)

0.0009

MSI-H

Tertile 3

20

1 (5)

Ref.

 

10

0 (0)

Ref.

 

Tertile 2 (− 4.32247)

27

2 (7)

NC

 

10

1 (10)

NC

 

Tertile 1 (− 3.92950)

18

3 (17)

NC

NC

6

2 (33)

NC

NC

BRAF mutation

Negative

Tertile 3

185

34 (18)

Ref.

 

115

22 (19)

Ref.

 

Tertile 2 (− 4.32247)

171

28 (16)

1.23 (0.74–2.07)

 

81

19 (23)

1.53 (0.81–2.91)

 

Tertile 1 (− 3.92950)

166

61 (37)

3.24 (2.09–5.02)

< 0.0001

93

34 (37)

2.72 (1.53–4.85)

0.0007

Positive

Tertile 3

10

2 (20)

Ref.

 

9

3 (33)

Ref.

 

Tertile 2 (− 4.32247)

17

3 (18)

NC

 

8

3 (38)

NC

 

Tertile 1 (− 3.92950)

19

8 (42)

NC

NC

2

1 (50)

NC

NC

Tumor location

Proximal colon

Tertile 3

59

5 (8)

Ref.

 

40

10 (25)

Ref.

 

Tertile 2 (− 4.32247)

80

11 (14)

2.60 (0.87–7.84)

 

27

6 (22)

0.99 (0.31–3.13)

 

Tertile 1 (− 3.92950)

71

25 (35)

6.92 (2.46–19.4)

< 0.0001

41

14 (34)

2.05 (0.79–5.34)

0.1176

Distal colon

Tertile 3

71

19 (27)

Ref.

 

41

5 (12)

Ref.

 

Tertile 2 (− 4.32247)

49

5 (10)

0.73 (0.25–2.14)

 

26

8 (31)

1.76 (0.51–6.09)

 

Tertile 1 (− 3.92950)

56

20 (36)

2.03 (1.05–3.94)

0.0477

21

8 (38)

6.00 (1.61–22.4)

0.0098

Rectum proximal

Tertile 3

65

12 (18)

Ref.

 

43

10 (23)

Ref.

 

Tertile 2 (− 4.32247)

59

15 (25)

1.36 (0.62–3.01)

 

36

8 (22)

3.48 (0.97–12.4)

 

Tertile 1 (− 3.92950)

58

24 (41)

3.59 (1.64–7.87)

0.0012

33

13 (39)

4.02 (1.38–11.7)

0.0129

  1. Abbreviations: CI confidence interval, HR hazard ratio, NC not calculated (< 5 patients)
  2. aCox regression adjusted for age, sex, tumor stage, tumor location, chemotherapy, MSI status, and BRAF mutation status
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Clinical Epigenetics

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