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Table 1 Association of methylation at the seven identified CpG sites with disease-specific survival in the study cohort and the validation cohort

From: A prognostic CpG score derived from epigenome-wide profiling of tumor tissue was independently associated with colorectal cancer survival

CpG sitesMethylation levelStudy cohortValidation cohort
NDeaths (%)HR (95% CI)ap value of trendNDeaths (%)HR (95% CI)ap value of trend
cg16935707β valueb568 1.43 (1.22–1.67)< 0.0001308 1.33 (1.09–1.61)0.0046
Tertile 319345 (23)Ref. 12527 (22)Ref. 
Tertile 2 (0.84342)18238 (21)1.53 (0.98–2.39) 9925 (25)1.95 (1.08–3.52) 
Tertile 1 (0.72736)19353 (27)2.22 (1.46–3.36)0.00028430 (36)2.12 (1.20–3.74)0.0095
cg05481217β valueb568 1.43 (1.22–1.67)< 0.0001308 1.30 (1.06–1.60)0.0115
Tertile 318736 (19)Ref. 17342 (24)Ref. 
Tertile 2 (0.66890)18336 (20)1.29 (0.79–2.08) 7817 (22)1.27 (0.71–2.27) 
Tertile 1 (0.61265)19864 (32)2.23 (1.46–3.42)0.00025723 (40)2.02 (1.18–3.45)0.0125
cg08044454β valueb568 1.44 (1.22–1.69)< 0.0001308 1.39 (1.14–1.70)0.0014
Tertile 319540 (21)Ref. 11020 (18)Ref. 
Tertile 2 (0.71507)19541 (21)1.25 (0.80–1.97) 9828 (29)1.87 (1.03–3.42) 
Tertile 1 (0.57145)17855 (31)2.23 (1.44–3.46)0.000310034 (34)2.48 (1.39–4.44)0.0021
cg01552551β valueb568 1.43 (1.22–1.68)< 0.0001308 1.28 (1.04–1.58)0.0215
Tertile 318928 (15)Ref. 10425 (24)Ref. 
Tertile 2 (0.72226)18949 (26)1.94 (1.21–3.10) 9522 (23)1.38 (0.76–2.51) 
Tertile 1 (0.59834)19059 (31)2.50 (1.58–3.95)< 0.000110935 (32)2.17 (1.24–3.79)0.0065
cg24311416β valueb568 1.43 (1.21–1.71)< 0.0001308 1.32 (1.04–1.66)0.0209
Tertile 319040 (21)Ref. 11827 (23)Ref. 
Tertile 2 (0.65694)18538 (21)1.03 (0.64–1.64) 9023 (26)1.06 (0.59–1.89) 
Tertile 1 (0.53430)19358 (30)2.20 (1.45–3.35)0.000210032 (32)2.00 (1.17–3.43)0.0135
cg02425108β valueb568 1.40 (1.19–1.65)< 0.0001308 1.32 (1.04–1.66)0.0200
Tertile 320935 (17)Ref. 10427 (26)Ref. 
Tertile 2 (0.62299)17538 (22)1.78 (1.12–2.85) 10728 (26)1.32 (0.75–2.31) 
Tertile 1 (0.52523)18463 (34)2.44 (1.59–3.74)< 0.00019727 (28)1.68 (0.95–2.96)0.0727
cg15659052β valueb568 1.38 (1.17–1.63)0.0001308 1.37 (1.09–1.71)0.0062
Tertile 318330 (16)Ref. 11325 (22)Ref. 
Tertile 2 (0.53788)19338 (20)2.12 (1.28–3.51) 9217 (18)1.55 (0.80–2.99) 
Tertile 1 (0.40182)19268 (35)2.34 (1.50–3.67)0.000210340 (39)1.99 (1.16–3.34)0.0118
  1. Abbreviations: HR hazard ratio, CI confidence interval
  2. aCox regression analyses adjusted for age, sex, tumor stage, tumor location, chemotherapy, MSI status, and BRAF mutation status
  3. bHR calculated for per unit decrease of the Z score of the β values