TY - JOUR AU - Abd El-Kader, S. M. AU - El-Den Ashmawy, E. M. S. PY - 2015 DA - 2015// TI - Non-alcoholic fatty liver disease: the diagnosis and management JO - World J Hepatol VL - 7 UR - https://doi.org/10.4254/wjh.v7.i6.846 DO - 10.4254/wjh.v7.i6.846 ID - Abd El-Kader2015 ER - TY - JOUR AU - Ratziu, V. AU - Goodman, Z. AU - Sanyal, A. PY - 2015 DA - 2015// TI - Current efforts and trends in the treatment of NASH JO - J Hepatol VL - 62 UR - https://doi.org/10.1016/j.jhep.2015.02.041 DO - 10.1016/j.jhep.2015.02.041 ID - Ratziu2015 ER - TY - JOUR AU - Valenti, L. AU - Bugianesi, E. AU - Pajvani, U. AU - Targher, G. PY - 2016 DA - 2016// TI - Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? JO - Liver Int VL - 36 UR - https://doi.org/10.1111/liv.13185 DO - 10.1111/liv.13185 ID - Valenti2016 ER - TY - JOUR AU - George, J. AU - Liddle, C. AU - Samarasinghe, D. AU - Lin, R. AU - Karim, R. AU - Hui, J. M. PY - 2002 DA - 2002// TI - NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome JO - Hepatology VL - 35 UR - https://doi.org/10.1053/jhep.2002.30692 DO - 10.1053/jhep.2002.30692 ID - George2002 ER - TY - JOUR AU - Romero-Gómez, M. AU - Zelber-Sagi, S. AU - Trenell, M. PY - 2017 DA - 2017// TI - Treatment of NAFLD with diet, physical activity and exercise JO - J Hepatol VL - 67 UR - https://doi.org/10.1016/j.jhep.2017.05.016 DO - 10.1016/j.jhep.2017.05.016 ID - Romero-Gómez2017 ER - TY - JOUR AU - Hollebecque, A. AU - Pattou, F. AU - Pigeyre, M. AU - Leteurtre, E. AU - Dharancy, S. AU - Louvet, A. PY - 2009 DA - 2009// TI - Prospective study of the long-term effects of bariatric surgery on liver injury in patients without advanced disease JO - Gastroenterology VL - 137 UR - https://doi.org/10.1053/j.gastro.2009.04.052 DO - 10.1053/j.gastro.2009.04.052 ID - Hollebecque2009 ER - TY - JOUR AU - Lotia, S. AU - Bellamy, M. C. PY - 2008 DA - 2008// TI - Anaesthesia and morbid obesity JO - Contin Educ Anaesthesia Crit Care Pain VL - 8 UR - https://doi.org/10.1093/bjaceaccp/mkn030 DO - 10.1093/bjaceaccp/mkn030 ID - Lotia2008 ER - TY - JOUR AU - Lee, Y. AU - Doumouras, A. G. AU - Yu, J. AU - Brar, K. AU - Banfield, L. AU - Gmora, S. PY - 2018 DA - 2018// TI - Complete resolution of nonalcoholic fatty liver disease after bariatric surgery: a systematic review and meta-analysis JO - Clin Gastroenterol Hepatol VL - 17 UR - https://doi.org/10.1016/j.cgh.2018.10.017 DO - 10.1016/j.cgh.2018.10.017 ID - Lee2018 ER - TY - JOUR AU - Buzzetti, E. AU - Pinzani, M. AU - Tsochatzis, E. A. PY - 2016 DA - 2016// TI - The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD) JO - Metabolism VL - 65 UR - https://doi.org/10.1016/j.metabol.2015.12.012 DO - 10.1016/j.metabol.2015.12.012 ID - Buzzetti2016 ER - TY - JOUR AU - Day, C. P. AU - James, O. F. W. PY - 1998 DA - 1998// TI - Steatohepatitis: a tale of two “hits”? JO - Gastroenterology VL - 114 UR - https://doi.org/10.1016/S0016-5085(98)70599-2 DO - 10.1016/S0016-5085(98)70599-2 ID - Day1998 ER - TY - JOUR AU - Fang, Y. a. n. -. L. a. n. AU - Chen, H. o. n. g. AU - Wang, C. h. u. n. -. L. i. n. AU - Liang, L. i. PY - 2018 DA - 2018// TI - Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model” JO - World Journal of Gastroenterology VL - 24 UR - https://doi.org/10.3748/wjg.v24.i27.2974 DO - 10.3748/wjg.v24.i27.2974 ID - Fang2018 ER - TY - JOUR AU - Nielsen, S. AU - Guo, Z. K. AU - Johnson, C. M. AU - Hensrud, D. D. AU - Jensen, M. D. PY - 2004 DA - 2004// TI - Splanchnic lipolysis in human obesity JO - J Clin Invest VL - 113 UR - https://doi.org/10.1172/JCI21047 DO - 10.1172/JCI21047 ID - Nielsen2004 ER - TY - JOUR AU - Kamagate, A. AU - Kim, D. H. AU - Zhang, T. AU - Slusher, S. AU - Gramignoli, R. AU - Strom, S. C. PY - 2010 DA - 2010// TI - FoxO1 links hepatic insulin action to endoplasmic reticulum stress JO - Endocrinology VL - 151 UR - https://doi.org/10.1210/en.2009-1306 DO - 10.1210/en.2009-1306 ID - Kamagate2010 ER - TY - JOUR AU - Svedberg, J. AU - Björntorp, P. AU - Smith, U. AU - Lönnroth, P. PY - 1990 DA - 1990// TI - Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes JO - Diabetes VL - 39 UR - https://doi.org/10.2337/diab.39.5.570 DO - 10.2337/diab.39.5.570 ID - Svedberg1990 ER - TY - JOUR AU - Lambert, J. E. AU - Ramos-Roman, M. A. AU - Browning, J. D. AU - Parks, E. J. PY - 2014 DA - 2014// TI - Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease JO - Gastroenterology VL - 146 UR - https://doi.org/10.1053/j.gastro.2013.11.049 DO - 10.1053/j.gastro.2013.11.049 ID - Lambert2014 ER - TY - JOUR AU - Brunt, E. M. AU - Tiniakos, D. G. PY - 2010 DA - 2010// TI - Histopathology of nonalcoholic fatty liver disease JO - World J Gastroenterol VL - 16 UR - https://doi.org/10.3748/wjg.v16.i42.5286 DO - 10.3748/wjg.v16.i42.5286 ID - Brunt2010 ER - TY - JOUR AU - Donnelly, K. L. AU - Smith, C. I. AU - Schwarzenberg, S. J. AU - Jessurun, J. AU - Boldt, M. D. AU - Parks, E. J. PY - 2005 DA - 2005// TI - Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease JO - J Clin Invest VL - 115 UR - https://doi.org/10.1172/JCI200523621 DO - 10.1172/JCI200523621 ID - Donnelly2005 ER - TY - STD TI - Esler WP, Bence KK. Metabolic targets in nonalcoholic fatty liver disease. Cell Mol Gastroenterol Hepatol. 2019. https://doi.org/10.1016/j.jcmgh.2019.04.007. ID - ref18 ER - TY - JOUR AU - Newton, A. C. PY - 1995 DA - 1995// TI - Protein kinase C: Structure, function, and regulation JO - J Biol Chem VL - 270 UR - https://doi.org/10.1074/jbc.270.48.28495 DO - 10.1074/jbc.270.48.28495 ID - Newton1995 ER - TY - JOUR AU - Hribal, M. L. AU - D’Alfonso, R. AU - Giovannone, B. AU - Lauro, D. AU - Liu, Y. Y. AU - Borboni, P. PY - 2018 DA - 2018// TI - The sulfonylurea glimepiride regulates intracellular routing of the insulin-receptor complexes through their interaction with specific protein kinase C isoforms JO - Mol Pharmacol VL - 59 UR - https://doi.org/10.1124/mol.59.2.322 DO - 10.1124/mol.59.2.322 ID - Hribal2018 ER - TY - JOUR AU - Tang, Y. AU - Chen, A. PY - 2010 DA - 2010// TI - Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase JO - Br J Pharmacol VL - 161 UR - https://doi.org/10.1111/j.1476-5381.2010.00956.x DO - 10.1111/j.1476-5381.2010.00956.x ID - Tang2010 ER - TY - JOUR AU - Bechmann, L. P. AU - Hannivoort, R. A. AU - Gerken, G. AU - Hotamisligil, G. S. AU - Trauner, M. AU - Canbay, A. PY - 2012 DA - 2012// TI - The interaction of hepatic lipid and glucose metabolism in liver diseases JO - J Hepatol VL - 56 UR - https://doi.org/10.1016/j.jhep.2011.08.025 DO - 10.1016/j.jhep.2011.08.025 ID - Bechmann2012 ER - TY - JOUR AU - Sunny, N. E. AU - Parks, E. J. AU - Browning, J. D. AU - Burgess, S. C. PY - 2011 DA - 2011// TI - Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease JO - Cell Metab VL - 14 UR - https://doi.org/10.1016/j.cmet.2011.11.004 DO - 10.1016/j.cmet.2011.11.004 ID - Sunny2011 ER - TY - JOUR AU - Nagao, H. AU - Nishizawa, H. AU - Bamba, T. AU - Nakayama, Y. AU - Isozumi, N. AU - Nagamori, S. PY - 2017 DA - 2017// TI - Increased dynamics of tricarboxylic acid cycle and glutamate synthesis in obese adipose tissue: in vivo metabolic turnover analysis JO - J Biol Chem VL - 292 UR - https://doi.org/10.1074/jbc.M116.770172 DO - 10.1074/jbc.M116.770172 ID - Nagao2017 ER - TY - JOUR AU - Akram, M. PY - 2014 DA - 2014// TI - Citric acid cycle and role of its intermediates in metabolism JO - Cell Biochem Biophys VL - 68 UR - https://doi.org/10.1007/s12013-013-9750-1 DO - 10.1007/s12013-013-9750-1 ID - Akram2014 ER - TY - JOUR AU - McCommis, K. S. AU - Finck, B. N. PY - 2015 DA - 2015// TI - Mitochondrial pyruvate transport: a historical perspective and future research directions JO - Biochem J VL - 466 UR - https://doi.org/10.1042/BJ20141171 DO - 10.1042/BJ20141171 ID - McCommis2015 ER - TY - JOUR AU - Owen, O. E. AU - Kalhan, S. C. AU - Hanson, R. W. PY - 2002 DA - 2002// TI - The key role of anaplerosis and cataplerosis for citric acid cycle function JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.R200006200 DO - 10.1074/jbc.R200006200 ID - Owen2002 ER - TY - JOUR AU - Tannahill, G. M. AU - Curtis, A. M. AU - Adamik, J. AU - Palsson-Mcdermott, E. M. AU - McGettrick, A. F. AU - Goel, G. PY - 2013 DA - 2013// TI - Succinate is an inflammatory signal that induces IL-1β through HIF-1α JO - Nature VL - 496 UR - https://doi.org/10.1038/nature11986 DO - 10.1038/nature11986 ID - Tannahill2013 ER - TY - JOUR AU - Raimundo, N. AU - Baysal, B. E. AU - Shadel, G. S. PY - 2011 DA - 2011// TI - Revisiting the TCA cycle: signaling to tumor formation JO - Trends Mol Med VL - 17 UR - https://doi.org/10.1016/j.molmed.2011.06.001 DO - 10.1016/j.molmed.2011.06.001 ID - Raimundo2011 ER - TY - JOUR AU - Nagaraj, R. AU - Sharpley, M. S. AU - Chi, F. AU - Braas, D. AU - Zhou, Y. AU - Kim, R. PY - 2017 DA - 2017// TI - Nuclear localization of mitochondrial TCA cycle enzymes as a critical step in mammalian zygotic genome activation JO - Cell VL - 168 UR - https://doi.org/10.1016/j.cell.2016.12.026 DO - 10.1016/j.cell.2016.12.026 ID - Nagaraj2017 ER - TY - JOUR AU - Wang, C. AU - Chen, H. AU - Zhang, J. AU - Hong, Y. AU - Ding, X. AU - Ying, W. PY - 2014 DA - 2014// TI - Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells JO - Int J Physiol Pathophysiol Pharmacol VL - 6 ID - Wang2014 ER - TY - JOUR AU - Purohit, V. AU - Gao, B. AU - Song, B. J. PY - 2009 DA - 2009// TI - Molecular mechanisms of alcoholic fatty liver JO - Alcohol Clin Exp Res VL - 33 UR - https://doi.org/10.1111/j.1530-0277.2008.00827.x DO - 10.1111/j.1530-0277.2008.00827.x ID - Purohit2009 ER - TY - JOUR AU - Goldberg, M. AU - Singer, E. AU - Yogev, O. AU - Shaulian, E. AU - Fox, T. D. AU - Pines, O. PY - 2010 DA - 2010// TI - Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response JO - PLoS Biol VL - 8 UR - https://doi.org/10.1371/journal.pbio.1000328 DO - 10.1371/journal.pbio.1000328 ID - Goldberg2010 ER - TY - JOUR AU - Brekke, E. AU - Walls, A. B. AU - Nørfeldt, L. AU - Schousboe, A. AU - Waagepetersen, H. S. AU - Sonnewald, U. PY - 2012 DA - 2012// TI - Direct measurement of backflux between oxaloacetate and fumarate following pyruvate carboxylation JO - Glia VL - 60 UR - https://doi.org/10.1002/glia.21265 DO - 10.1002/glia.21265 ID - Brekke2012 ER - TY - JOUR AU - Sutherland, G. AU - Tyson, R. AU - Auer, R. PY - 2008 DA - 2008// TI - Truncation of the Krebs cycle during hypoglycemic coma JO - Med Chem (Los Angeles) VL - 4 UR - https://doi.org/10.2174/157340608784872235 DO - 10.2174/157340608784872235 ID - Sutherland2008 ER - TY - JOUR AU - Tyrakis, P. A. AU - Yurkovich, M. E. AU - Sciacovelli, M. AU - Papachristou, E. K. AU - Bridges, H. R. AU - Gaude, E. PY - 2017 DA - 2017// TI - Fumarate hydratase loss causes combined respiratory chain defects JO - Cell Rep VL - 21 UR - https://doi.org/10.1016/j.celrep.2017.09.092 DO - 10.1016/j.celrep.2017.09.092 ID - Tyrakis2017 ER - TY - JOUR AU - Nassir, F. AU - Ibdah, J. A. PY - 2015 DA - 2015// TI - Role of mitochondria in nonalcoholic fatty liver disease JO - Int J Mol Sci VL - 15 UR - https://doi.org/10.3390/ijms15058713 DO - 10.3390/ijms15058713 ID - Nassir2015 ER - TY - JOUR AU - Fabbrini, E. AU - Mohammed, B. S. AU - Magkos, F. AU - Korenblat, K. M. AU - Patterson, B. W. AU - Klein, S. PY - 2008 DA - 2008// TI - Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease JO - Gastroenterology VL - 134 UR - https://doi.org/10.1053/j.gastro.2007.11.038 DO - 10.1053/j.gastro.2007.11.038 ID - Fabbrini2008 ER - TY - JOUR AU - McGarry, J. D. AU - Foster, D. W. PY - 1980 DA - 1980// TI - Regulation of hepatic fatty acid oxidation and ketone body production JO - Annu Rev Biochem VL - 49 UR - https://doi.org/10.1146/annurev.bi.49.070180.002143 DO - 10.1146/annurev.bi.49.070180.002143 ID - McGarry1980 ER - TY - JOUR AU - Handa, P. AU - Maliken, B. D. AU - Nelson, J. E. AU - Morgan-Stevenson, V. AU - Messner, D. J. AU - Dhillon, B. K. PY - 2014 DA - 2014// TI - Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis JO - Hepatology VL - 60 UR - https://doi.org/10.1002/hep.26946 DO - 10.1002/hep.26946 ID - Handa2014 ER - TY - JOUR AU - Satapati, S. AU - Kucejova, B. AU - Duarte, J. A. G. AU - Fletcher, J. A. AU - Reynolds, L. AU - Sunny, N. E. PY - 2015 DA - 2015// TI - Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver JO - J Clin Invest VL - 125 UR - https://doi.org/10.1172/JCI82204 DO - 10.1172/JCI82204 ID - Satapati2015 ER - TY - JOUR AU - Begriche, K. AU - Igoudjil, A. AU - Pessayre, D. AU - Fromenty, B. PY - 2006 DA - 2006// TI - Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it JO - Mitochondrion VL - 6 UR - https://doi.org/10.1016/j.mito.2005.10.004 DO - 10.1016/j.mito.2005.10.004 ID - Begriche2006 ER - TY - JOUR AU - Mailloux, R. J. AU - Harper, M. E. PY - 2011 DA - 2011// TI - Uncoupling proteins and the control of mitochondrial reactive oxygen species production JO - Free Radic Biol Med VL - 51 UR - https://doi.org/10.1016/j.freeradbiomed.2011.06.022 DO - 10.1016/j.freeradbiomed.2011.06.022 ID - Mailloux2011 ER - TY - JOUR AU - Serviddio, G. AU - Bellanti, F. AU - Tamborra, R. AU - Rollo, T. AU - Capitanio, N. AU - Romano, A. D. PY - 2008 DA - 2008// TI - Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury JO - Gut VL - 57 UR - https://doi.org/10.1136/gut.2007.147496 DO - 10.1136/gut.2007.147496 ID - Serviddio2008 ER - TY - JOUR AU - Miwa, S. AU - Brand, M. D. PY - 2003 DA - 2003// TI - Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling JO - Biochem Soc Trans VL - 31 UR - https://doi.org/10.1042/bst0311300 DO - 10.1042/bst0311300 ID - Miwa2003 ER - TY - JOUR AU - Kaneko, S. AU - Misu, H. AU - Nabemoto, S. AU - Ando, H. AU - Kurita, S. AU - Miyamoto, K. -. I. PY - 2009 DA - 2009// TI - Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.m901488200 DO - 10.1074/jbc.m901488200 ID - Kaneko2009 ER - TY - JOUR AU - Clarke, J. D. AU - Novak, P. AU - Lake, A. D. AU - Shipkova, P. AU - Aranibar, N. AU - Robertson, D. PY - 2014 DA - 2014// TI - Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease JO - Dig Dis Sci VL - 59 UR - https://doi.org/10.1007/s10620-013-2873-9 DO - 10.1007/s10620-013-2873-9 ID - Clarke2014 ER - TY - JOUR AU - Huan, T. AU - Troyer, D. A. AU - Li, L. PY - 2016 DA - 2016// TI - Metabolite analysis and histology on the exact same tissue: Comprehensive metabolomic profiling and metabolic classification of prostate cancer JO - Sci Rep VL - 6 UR - https://doi.org/10.1038/srep32272 DO - 10.1038/srep32272 ID - Huan2016 ER - TY - JOUR AU - Patterson, R. a. i. n. e. y. E. AU - Kalavalapalli, S. r. i. l. a. x. m. i. AU - Williams, C. a. r. o. l. i. n. e. M. AU - Nautiyal, M. a. n. i. s. h. a. AU - Mathew, J. u. s. t. i. n. T. AU - Martinez, J. a. n. i. e. AU - Reinhard, M. a. r. y. K. AU - McDougall, D. a. n. i. e. l. l. e. J. AU - Rocca, J. a. m. e. s. R. AU - Yost, R. i. c. h. a. r. d. A. AU - Cusi, K. e. n. n. e. t. h. AU - Garrett, T. i. m. o. t. h. y. J. AU - Sunny, N. i. s. h. a. n. t. h. E. PY - 2016 DA - 2016// TI - Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity JO - American Journal of Physiology-Endocrinology and Metabolism VL - 310 UR - https://doi.org/10.1152/ajpendo.00492.2015 DO - 10.1152/ajpendo.00492.2015 ID - Patterson2016 ER - TY - JOUR AU - Lyall, M. J. AU - Cartier, J. AU - Thomson, J. P. AU - Cameron, K. AU - Meseguer-Ripolles, J. AU - O’Duibhir, E. PY - 2018 DA - 2018// TI - Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells JO - Philos Trans R Soc B Biol Sci VL - 373 UR - https://doi.org/10.1098/rstb.2017.0362 DO - 10.1098/rstb.2017.0362 ID - Lyall2018 ER - TY - JOUR AU - McDonough, M. A. AU - Loenarz, C. AU - Chowdhury, R. AU - Clifton, I. J. AU - Schofield, C. J. PY - 2010 DA - 2010// TI - Structural studies on human 2-oxoglutarate dependent oxygenases JO - Curr Opin Struct Biol VL - 20 UR - https://doi.org/10.1016/j.sbi.2010.08.006 DO - 10.1016/j.sbi.2010.08.006 ID - McDonough2010 ER - TY - JOUR AU - Laukka, T. AU - Mariani, C. J. AU - Ihantola, T. AU - Cao, J. Z. AU - Hokkanen, J. AU - Kaelin, W. G. PY - 2016 DA - 2016// TI - Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes JO - J Biol Chem VL - 291 UR - https://doi.org/10.1074/jbc.M115.688762 DO - 10.1074/jbc.M115.688762 ID - Laukka2016 ER - TY - JOUR AU - Roach, P. L. AU - Clifton, I. J. AU - Fülöp, V. AU - Harlos, K. AU - Barton, G. J. AU - Hajdu, J. PY - 1995 DA - 1995// TI - Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes JO - Nature VL - 375 UR - https://doi.org/10.1038/375700a0 DO - 10.1038/375700a0 ID - Roach1995 ER - TY - JOUR AU - Hausinger, R. P. PY - 2004 DA - 2004// TI - Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes JO - Crit Rev Biochem Mol Biol VL - 39 UR - https://doi.org/10.1080/10409230490440541 DO - 10.1080/10409230490440541 ID - Hausinger2004 ER - TY - JOUR AU - Xiao, M. AU - Yang, H. AU - Xu, W. AU - Ma, S. AU - Lin, H. AU - Zhu, H. PY - 2012 DA - 2012// TI - Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors JO - Genes Dev VL - 26 UR - https://doi.org/10.1101/gad.191056.112 DO - 10.1101/gad.191056.112 ID - Xiao2012 ER - TY - JOUR AU - Tahiliani, M. AU - Koh, K. P. AU - Shen, Y. AU - Pastor, W. A. AU - Bandukwala, H. AU - Brudno, Y. PY - 2009 DA - 2009// TI - Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 JO - Science (80- ) VL - 324 UR - https://doi.org/10.1126/science.1170116 DO - 10.1126/science.1170116 ID - Tahiliani2009 ER - TY - JOUR AU - Pollard, P. J. AU - Loenarz, C. AU - Mole, D. R. AU - McDonough, M. A. AU - Gleadle, J. M. AU - Schofield, C. J. PY - 2008 DA - 2008// TI - Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α JO - Biochem J VL - 416 UR - https://doi.org/10.1016/S0041-1345(99)00166-9 DO - 10.1016/S0041-1345(99)00166-9 ID - Pollard2008 ER - TY - JOUR AU - Stiehl, D. P. AU - Wirthner, R. AU - Köditz, J. AU - Spielmann, P. AU - Camenisch, G. AU - Wenger, R. H. PY - 2006 DA - 2006// TI - Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels: evidence for an autoregulatory oxygen-sensing system JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M601719200 DO - 10.1074/jbc.M601719200 ID - Stiehl2006 ER - TY - JOUR AU - Thyfault, J. P. AU - Rector, R. S. AU - Uptergrove, G. M. AU - Borengasser, S. J. AU - Morris, E. M. AU - Wei, Y. PY - 2009 DA - 2009// TI - Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury JO - J Physiol VL - 587 UR - https://doi.org/10.1113/jphysiol.2009.169060 DO - 10.1113/jphysiol.2009.169060 ID - Thyfault2009 ER - TY - JOUR AU - Rector, R. S. AU - Thyfault, J. P. AU - Uptergrove, G. M. AU - Morris, E. M. AU - Naples, S. P. AU - Borengasser, S. J. PY - 2010 DA - 2010// TI - Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model JO - J Hepatol VL - 52 UR - https://doi.org/10.1016/J.JHEP.2009.11.030 DO - 10.1016/J.JHEP.2009.11.030 ID - Rector2010 ER - TY - JOUR AU - Cuyàs, E. AU - Fernández-Arroyo, S. AU - Verdura, S. AU - García, R. Á. -. F. AU - Stursa, J. AU - Werner, L. PY - 2018 DA - 2018// TI - Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism JO - Oncogene VL - 37 UR - https://doi.org/10.1038/onc.2017.367 DO - 10.1038/onc.2017.367 ID - Cuyàs2018 ER - TY - JOUR AU - Gorres, K. L. AU - Raines, R. T. PY - 2010 DA - 2010// TI - Prolyl 4-hydroxylase JO - Crit Rev Biochem Mol Biol VL - 45 UR - https://doi.org/10.3109/10409231003627991 DO - 10.3109/10409231003627991 ID - Gorres2010 ER - TY - JOUR AU - Qi, H. H. AU - Ongusaha, P. P. AU - Myllyharju, J. AU - Cheng, D. AU - Pakkanen, O. AU - Shi, Y. PY - 2008 DA - 2008// TI - Prolyl 4-hydroxylation regulates Argonaute 2 stability JO - Nature VL - 455 UR - https://doi.org/10.1038/nature07186 DO - 10.1038/nature07186 ID - Qi2008 ER - TY - JOUR AU - Hutton, J. J. AU - Kaplan, A. AU - Udenfriend, S. PY - 1967 DA - 1967// TI - Conversion of the amino acid sequence Gly-Pro-Pro in protein to Gly-Pro-Hyp by collagen proline hydroxylase JO - Arch Biochem Biophys VL - 121 UR - https://doi.org/10.1016/0003-9861(67)90091-4 DO - 10.1016/0003-9861(67)90091-4 ID - Hutton1967 ER - TY - JOUR AU - Bhatnagar, R. S. AU - Rapaka, R. S. AU - Urry, D. W. PY - 1978 DA - 1978// TI - Interaction of polypeptide models of elastin with prolyl hydroxylase JO - FEBS Lett VL - 95 UR - https://doi.org/10.1016/0014-5793(78)80052-0 DO - 10.1016/0014-5793(78)80052-0 ID - Bhatnagar1978 ER - TY - JOUR AU - Ke, Q. AU - Costa, M. PY - 2006 DA - 2006// TI - Hypoxia-inducible factor-1 (HIF-1) JO - Mol Pharmacol VL - 70 UR - https://doi.org/10.1124/mol.106.027029 DO - 10.1124/mol.106.027029 ID - Ke2006 ER - TY - JOUR AU - Koh, M. Y. AU - Darnay, B. G. AU - Powis, G. PY - 2008 DA - 2008// TI - Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1, leading to its oxygen-independent degradation JO - Mol Cell Biol VL - 28 UR - https://doi.org/10.1128/MCB.00773-08 DO - 10.1128/MCB.00773-08 ID - Koh2008 ER - TY - JOUR AU - Chua, Y. L. AU - Dufour, E. AU - Dassa, E. P. AU - Rustin, P. AU - Jacobs, H. T. AU - Taylor, C. T. PY - 2010 DA - 2010// TI - Stabilization of hypoxia-inducible factor-1α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.158485 DO - 10.1074/jbc.M110.158485 ID - Chua2010 ER - TY - JOUR AU - Selak, M. A. AU - Armour, S. M. AU - MacKenzie, E. D. AU - Boulahbel, H. AU - Watson, D. G. AU - Mansfield, K. D. PY - 2005 DA - 2005// TI - Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase JO - Cancer Cell VL - 7 UR - https://doi.org/10.1016/j.ccr.2004.11.022 DO - 10.1016/j.ccr.2004.11.022 ID - Selak2005 ER - TY - JOUR AU - Koivunen, P. AU - Hirsilä, M. AU - Remes, A. M. AU - Hassinen, I. E. AU - Kivirikko, K. I. AU - Myllyharju, J. PY - 2007 DA - 2007// TI - Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M610415200 DO - 10.1074/jbc.M610415200 ID - Koivunen2007 ER - TY - JOUR AU - Furuta, E. AU - Pai, S. K. AU - Zhan, R. AU - Bandyopadhyay, S. AU - Watabe, M. AU - Mo, Y. Y. PY - 2008 DA - 2008// TI - Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1 JO - Cancer Res VL - 68 UR - https://doi.org/10.1158/0008-5472.CAN-07-2489 DO - 10.1158/0008-5472.CAN-07-2489 ID - Furuta2008 ER - TY - JOUR AU - Carabelli, J. AU - Burgueño, A. L. AU - Rosselli, M. S. AU - Gianotti, T. F. AU - Lago, N. R. AU - Pirola, C. J. PY - 2011 DA - 2011// TI - High fat diet-induced liver steatosis promotes an increase in liver mitochondrial biogenesis in response to hypoxia JO - J Cell Mol Med VL - 15 UR - https://doi.org/10.1111/j.1582-4934.2010.01128.x DO - 10.1111/j.1582-4934.2010.01128.x ID - Carabelli2011 ER - TY - JOUR AU - Kietzmann, T. AU - Cornesse, Y. AU - Brechtel, K. AU - Modaressi, S. AU - Jungermann, K. PY - 2001 DA - 2001// TI - Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver JO - Biochem J VL - 354 UR - https://doi.org/10.1042/bj3540531 DO - 10.1042/bj3540531 ID - Kietzmann2001 ER - TY - JOUR AU - Krishnan, J. AU - Danzer, C. AU - Simka, T. AU - Ukropec, J. AU - Walter, K. M. AU - Kumpf, S. PY - 2012 DA - 2012// TI - Dietary obesity-associated hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system JO - Genes Dev VL - 26 UR - https://doi.org/10.1101/gad.180406.111 DO - 10.1101/gad.180406.111 ID - Krishnan2012 ER - TY - JOUR AU - Hosogai, N. AU - Fukuhara, A. AU - Oshima, K. AU - Miyata, Y. AU - Tanaka, S. AU - Segawa, K. PY - 2007 DA - 2007// TI - Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation JO - Diabetes VL - 56 UR - https://doi.org/10.2337/db06-0911 DO - 10.2337/db06-0911 ID - Hosogai2007 ER - TY - JOUR AU - Rausch, M. E. AU - Weisberg, S. AU - Vardhana, P. AU - Tortoriello, D. V. PY - 2008 DA - 2008// TI - Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration JO - Int J Obes VL - 32 UR - https://doi.org/10.1038/sj.ijo.0803744 DO - 10.1038/sj.ijo.0803744 ID - Rausch2008 ER - TY - JOUR AU - Mesarwi, O. A. AU - Shin, M. -. K. AU - Bevans-Fonti, S. AU - Schlesinger, C. AU - Shaw, J. AU - Polotsky, V. Y. PY - 2016 DA - 2016// TI - Hepatocyte hypoxia inducible factor-1 mediates the development of liver fibrosis in a mouse model of nonalcoholic fatty liver disease JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0168572 DO - 10.1371/journal.pone.0168572 ID - Mesarwi2016 ER - TY - JOUR AU - Musselman, C. A. AU - Mansfield, R. E. AU - Garske, A. L. AU - Davrazou, F. AU - Kwan, A. H. AU - Oliver, S. S. PY - 2009 DA - 2009// TI - Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications JO - Biochem J VL - 423 UR - https://doi.org/10.1042/bj20090870 DO - 10.1042/bj20090870 ID - Musselman2009 ER - TY - JOUR AU - Mariño-Ramírez, L. AU - Kann, M. G. AU - Shoemaker, B. A. AU - Landsman, D. PY - 2005 DA - 2005// TI - Histone structure and nucleosome stability JO - Expert Rev Proteomics VL - 2 UR - https://doi.org/10.1586/14789450.2.5.719 DO - 10.1586/14789450.2.5.719 ID - Mariño-Ramírez2005 ER - TY - JOUR AU - Venkatesh, S. AU - Workman, J. L. PY - 2015 DA - 2015// TI - Histone exchange, chromatin structure and the regulation of transcription JO - Nat Rev Mol Cell Biol VL - 16 UR - https://doi.org/10.1038/nrm3941 DO - 10.1038/nrm3941 ID - Venkatesh2015 ER - TY - JOUR AU - Nathan, D. AU - Sterner, D. E. AU - Berger, S. L. PY - 2003 DA - 2003// TI - Histone modifications: now summoning sumoylation JO - Proc Natl Acad Sci VL - 100 UR - https://doi.org/10.1073/pnas.2436173100 DO - 10.1073/pnas.2436173100 ID - Nathan2003 ER - TY - JOUR AU - Tamaru, H. PY - 2010 DA - 2010// TI - Confining euchromatin/heterochromatin territory: Jumonji crosses the line JO - Genes Dev VL - 24 UR - https://doi.org/10.1101/gad.1941010 DO - 10.1101/gad.1941010 ID - Tamaru2010 ER - TY - JOUR AU - Anand, R. AU - Marmorstein, R. PY - 2007 DA - 2007// TI - Structure and mechanism of lysine-specific demethylase enzymes JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.R700027200 DO - 10.1074/jbc.R700027200 ID - Anand2007 ER - TY - JOUR AU - Klose, R. J. AU - Kallin, E. M. AU - Zhang, Y. PY - 2006 DA - 2006// TI - JmjC-domain-containing proteins and histone demethylation JO - Nat Rev Genet VL - 7 UR - https://doi.org/10.1038/nrg1945 DO - 10.1038/nrg1945 ID - Klose2006 ER - TY - JOUR AU - Martin, C. AU - Zhang, Y. PY - 2005 DA - 2005// TI - The diverse functions of histone lysine methylation JO - Nat Rev Mol Cell Biol VL - 6 UR - https://doi.org/10.1038/nrm1761 DO - 10.1038/nrm1761 ID - Martin2005 ER - TY - JOUR AU - Vakoc, C. R. AU - Mandat, S. A. AU - Olenchock, B. A. AU - Blobel, G. A. PY - 2005 DA - 2005// TI - Histone H3 lysine 9 methylation and HP1γ are associated with transcription elongation through mammalian chromatin JO - Mol Cell VL - 19 UR - https://doi.org/10.1016/j.molcel.2005.06.011 DO - 10.1016/j.molcel.2005.06.011 ID - Vakoc2005 ER - TY - JOUR AU - Cervera, A. M. AU - Bayley, J. P. AU - Devilee, P. AU - McCreath, K. J. PY - 2009 DA - 2009// TI - Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells JO - Mol Cancer VL - 8 UR - https://doi.org/10.1186/1476-4598-8-89 DO - 10.1186/1476-4598-8-89 ID - Cervera2009 ER - TY - JOUR AU - Jun, H. J. AU - Kim, J. AU - Hoang, M. H. AU - Lee, S. J. PY - 2012 DA - 2012// TI - Hepatic lipid accumulation alters global histone H3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0044345 DO - 10.1371/journal.pone.0044345 ID - Jun2012 ER - TY - JOUR AU - Robertson, K. D. PY - 2005 DA - 2005// TI - DNA methylation and human disease JO - Nat Rev Genet VL - 6 UR - https://doi.org/10.1038/nrg1655 DO - 10.1038/nrg1655 ID - Robertson2005 ER - TY - JOUR AU - Smith, Z. D. AU - Meissner, A. PY - 2013 DA - 2013// TI - DNA methylation: roles in mammalian development JO - Nat Rev Genet VL - 14 UR - https://doi.org/10.1038/nrg3354 DO - 10.1038/nrg3354 ID - Smith2013 ER - TY - JOUR AU - Suzuki, M. M. AU - Bird, A. PY - 2008 DA - 2008// TI - DNA methylation landscapes: provocative insights from epigenomics JO - Nat Rev Genet VL - 9 UR - https://doi.org/10.1038/nrg2341 DO - 10.1038/nrg2341 ID - Suzuki2008 ER - TY - JOUR AU - Leitch, H. G. AU - Mcewen, K. R. AU - Turp, A. AU - Encheva, V. AU - Carroll, T. AU - Grabole, N. PY - 2013 DA - 2013// TI - Naive pluripotency is associated with global DNA hypomethylation JO - Nat Struct Mol Biol VL - 20 UR - https://doi.org/10.1038/nsmb.2510 DO - 10.1038/nsmb.2510 ID - Leitch2013 ER - TY - JOUR AU - Bachman, M. AU - Uribe-Lewis, S. AU - Yang, X. AU - Williams, M. AU - Murrell, A. AU - Balasubramanian, S. PY - 2014 DA - 2014// TI - 5-Hydroxymethylcytosine is a predominantly stable DNA modification JO - Nat Chem VL - 6 UR - https://doi.org/10.1038/nchem.2064 DO - 10.1038/nchem.2064 ID - Bachman2014 ER - TY - JOUR AU - Lin, I. H. AU - Chen, Y. F. AU - Hsu, M. T. PY - 2017 DA - 2017// TI - Correlated 5-hydroxymethylcytosine (5hmC) and gene expression profiles underpin gene and organ-specific epigenetic regulation in adult mouse brain and liver JO - PLoS One VL - 12 UR - https://doi.org/10.1371/journal.pone.0170779 DO - 10.1371/journal.pone.0170779 ID - Lin2017 ER - TY - JOUR AU - Putiri, E. L. AU - Tiedemann, R. L. AU - Thompson, J. J. AU - Liu, C. AU - Ho, T. AU - Choi, J. H. PY - 2014 DA - 2014// TI - Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells JO - Genome Biol VL - 15 UR - https://doi.org/10.1186/gb-2014-15-6-r81 DO - 10.1186/gb-2014-15-6-r81 ID - Putiri2014 ER - TY - JOUR AU - Wu, H. AU - D’Alessio, A. C. AU - Ito, S. AU - Wang, Z. AU - Cui, K. AU - Zhao, K. PY - 2011 DA - 2011// TI - Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells JO - Genes Dev VL - 25 UR - https://doi.org/10.1101/gad.2036011 DO - 10.1101/gad.2036011 ID - Wu2011 ER - TY - JOUR AU - Pogribny, I. P. AU - Tryndyak, V. P. AU - Bagnyukova, T. V. AU - Melnyk, S. AU - Montgomery, B. AU - Ross, S. A. PY - 2009 DA - 2009// TI - Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet JO - J Hepatol VL - 51 UR - https://doi.org/10.1016/j.jhep.2009.03.021 DO - 10.1016/j.jhep.2009.03.021 ID - Pogribny2009 ER - TY - JOUR AU - Lyall, M. J. AU - Cartier, J. AU - Richards, J. A. AU - Cobice, D. AU - Thomson, J. P. AU - Meehan, R. R. PY - 2017 DA - 2017// TI - Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD JO - Wellcome Open Res VL - 2 UR - https://doi.org/10.12688/wellcomeopenres.12199.1 DO - 10.12688/wellcomeopenres.12199.1 ID - Lyall2017 ER - TY - JOUR AU - Pirola, C. J. AU - Scian, R. AU - Gianotti, T. F. AU - Dopazo, H. AU - Rohr, C. AU - Martino, J. S. PY - 2015 DA - 2015// TI - Epigenetic modifications in the biology of nonalcoholic fatty liver disease: the role of DNA hydroxymethylation and TET proteins JO - Med (United States) VL - 94 UR - https://doi.org/10.1097/MD.0000000000001480 DO - 10.1097/MD.0000000000001480 ID - Pirola2015 ER - TY - JOUR AU - Gao, D. AU - Zhu, B. AU - Sun, H. AU - Wang, X. PY - 2017 DA - 2017// TI - Mitochondrial DNA methylation and related disease JO - Adv Exp Med Biol VL - 1038 UR - https://doi.org/10.1007/978-981-10-6674-0_9 DO - 10.1007/978-981-10-6674-0_9 ID - Gao2017 ER - TY - JOUR AU - Mechta, M. AU - Ingerslev, L. R. AU - Fabre, O. AU - Picard, M. AU - Barrès, R. PY - 2017 DA - 2017// TI - Evidence suggesting absence of mitochondrial DNA methylation JO - Front Genet VL - 8 UR - https://doi.org/10.3389/fgene.2017.00166 DO - 10.3389/fgene.2017.00166 ID - Mechta2017 ER - TY - JOUR AU - Hotta, K. AU - Kitamoto, T. AU - Kitamoto, A. AU - Ogawa, Y. AU - Honda, Y. AU - Kessoku, T. PY - 2018 DA - 2018// TI - Identification of the genomic region under epigenetic regulation during non-alcoholic fatty liver disease progression JO - Hepatol Res VL - 48 UR - https://doi.org/10.1111/hepr.12992 DO - 10.1111/hepr.12992 ID - Hotta2018 ER - TY - JOUR AU - Murphy, S. K. AU - Yang, H. AU - Moylan, C. A. AU - Pang, H. AU - Dellinger, A. AU - Abdelmalek, M. F. PY - 2013 DA - 2013// TI - Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease JO - Gastroenterology VL - 145 UR - https://doi.org/10.1053/J.GASTRO.2013.07.047 DO - 10.1053/J.GASTRO.2013.07.047 ID - Murphy2013 ER - TY - JOUR AU - Ahrens, M. AU - Ammerpohl, O. AU - Schönfels, W. AU - Kolarova, J. AU - Bens, S. AU - Itzel, T. PY - 2013 DA - 2013// TI - DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery JO - Cell Metab VL - 18 UR - https://doi.org/10.1016/j.cmet.2013.07.004 DO - 10.1016/j.cmet.2013.07.004 ID - Ahrens2013 ER - TY - JOUR AU - Hotta, K. AU - Kitamoto, A. AU - Kitamoto, T. AU - Ogawa, Y. AU - Honda, Y. AU - Kessoku, T. PY - 2018 DA - 2018// TI - Identification of differentially methylated region (DMR) networks associated with progression of nonalcoholic fatty liver disease JO - Sci Rep VL - 8 UR - https://doi.org/10.1038/s41598-018-31886-5 DO - 10.1038/s41598-018-31886-5 ID - Hotta2018 ER - TY - JOUR AU - Mello, V. D. AU - Matte, A. AU - Perfilyev, A. AU - Männistö, V. AU - Rönn, T. AU - Nilsson, E. PY - 2017 DA - 2017// TI - Human liver epigenetic alterations in non-alcoholic steatohepatitis are related to insulin action JO - Epigenetics VL - 12 UR - https://doi.org/10.1080/15592294.2017.1294305 DO - 10.1080/15592294.2017.1294305 ID - Mello2017 ER - TY - JOUR AU - Gerhard, G. S. AU - Malenica, I. AU - Llaci, L. AU - Chu, X. AU - Petrick, A. T. AU - Still, C. D. PY - 2018 DA - 2018// TI - Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways JO - Clin Epigenetics VL - 10 UR - https://doi.org/10.1186/s13148-018-0525-9 DO - 10.1186/s13148-018-0525-9 ID - Gerhard2018 ER - TY - JOUR AU - Sookoian, S. AU - Rosselli, M. S. AU - Gemma, C. AU - Burgueño, A. L. AU - Fernández Gianotti, T. AU - Castaño, G. O. PY - 2010 DA - 2010// TI - Epigenetic regulation of insulin resistance in nonalcoholic fatty liver disease: impact of liver methylation of the peroxisome proliferator-activated receptor γ coactivator 1α promoter JO - Hepatology VL - 52 UR - https://doi.org/10.1002/hep.23927 DO - 10.1002/hep.23927 ID - Sookoian2010 ER - TY - JOUR AU - Thomson, J. P. AU - Ottaviano, R. AU - Unterberger, E. B. AU - Lempiainen, H. AU - Muller, A. AU - Terranova, R. PY - 2016 DA - 2016// TI - Loss of tet1-associated5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer JO - Cancer Res VL - 76 UR - https://doi.org/10.1158/0008-5472.CAN-15-1910 DO - 10.1158/0008-5472.CAN-15-1910 ID - Thomson2016 ER - TY - JOUR AU - Wu, H. AU - D’Alessio, A. C. AU - Ito, S. AU - Xia, K. AU - Wang, Z. AU - Cui, K. PY - 2011 DA - 2011// TI - Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells JO - Nature VL - 473 UR - https://doi.org/10.1038/nature09934 DO - 10.1038/nature09934 ID - Wu2011 ER - TY - JOUR AU - Ge, W. AU - Xie, W. AU - Coskun, V. AU - Tao, J. AU - Li, E. AU - Yoshikawa, K. PY - 2010 DA - 2010// TI - Dnmt3a-dependent nonpromoter DNA methylation facilitates transcription of neurogenic genes JO - Science (80- ) VL - 329 UR - https://doi.org/10.1126/science.1190485 DO - 10.1126/science.1190485 ID - Ge2010 ER - TY - JOUR AU - Cao, R. AU - Wang, L. AU - Wang, H. AU - Xia, L. AU - Erdjument-Bromage, H. AU - Tempst, P. PY - 2002 DA - 2002// TI - Role of histone H3 lysine 27 methylation in polycomb-group silencing JO - Science (80- ) VL - 298 UR - https://doi.org/10.1126/science.1076997 DO - 10.1126/science.1076997 ID - Cao2002 ER - TY - JOUR AU - Kuzmichev, A. AU - Nishioka, K. AU - Erdjument-Bromage, H. AU - Tempst, P. AU - Reinberg, D. PY - 2002 DA - 2002// TI - Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein JO - Genes Dev VL - 16 UR - https://doi.org/10.1101/gad.1035902 DO - 10.1101/gad.1035902 ID - Kuzmichev2002 ER - TY - JOUR AU - Chen, Q. R. AU - Braun, R. AU - Hu, Y. AU - Yan, C. AU - Brunt, E. M. AU - Meerzaman, D. PY - 2013 DA - 2013// TI - Multi-SNP analysis of GWAS data identifies pathways associated with nonalcoholic fatty liver disease JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0065982 DO - 10.1371/journal.pone.0065982 ID - Chen2013 ER - TY - JOUR AU - Vella, S. AU - Gnani, D. AU - Crudele, A. AU - Ceccarelli, S. AU - Stefanis, C. AU - Gaspari, S. PY - 2013 DA - 2013// TI - EZH2 down-regulation exacerbates lipid accumulation and inflammation in in vitro and in vivo NAFLD JO - Int J Mol Sci VL - 14 UR - https://doi.org/10.3390/ijms141224154 DO - 10.3390/ijms141224154 ID - Vella2013 ER - TY - JOUR AU - Haltiwanger, R. S. AU - Blomberg, M. A. AU - Hart, G. W. PY - 1992 DA - 1992// TI - Glycosylation of nuclear and cytoplasmic proteins: purification and characterization of a uridine diphospho-N-acetylglucosamine:polypeptide β-N-acetylglucosaminyltransferase JO - J Biol Chem VL - 267 UR - https://doi.org/10.1006/bbrc.1997.6110 DO - 10.1006/bbrc.1997.6110 ID - Haltiwanger1992 ER - TY - STD TI - Hrit J, Goodrich L, Li C, Wang BA, Nie J, Cui X, et al. OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. Elife. 2018;7. https://doi.org/10.7554/eLife.34870. ID - ref117 ER - TY - JOUR AU - Kim, Y. H. AU - Nakayama, T. AU - Nayak, J. PY - 2018 DA - 2018// TI - Glycolysis and the hexosamine biosynthetic pathway as novel targets for upper and lower airway inflammation JO - Allergy Asthma Immunol Res VL - 10 UR - https://doi.org/10.4168/aair.2018.10.1.6 DO - 10.4168/aair.2018.10.1.6 ID - Kim2018 ER - TY - JOUR AU - Ferrer, C. M. AU - Lynch, T. P. AU - Sodi, V. L. AU - Falcone, J. N. AU - Schwab, L. P. AU - Peacock, D. L. PY - 2014 DA - 2014// TI - O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway JO - Mol Cell VL - 54 UR - https://doi.org/10.1016/j.molcel.2014.04.026 DO - 10.1016/j.molcel.2014.04.026 ID - Ferrer2014 ER - TY - JOUR AU - Bedogni, G. AU - Gastaldelli, A. AU - Tiribelli, C. AU - Agosti, F. AU - Col, A. AU - Fessehatsion, R. PY - 2014 DA - 2014// TI - Relationship between glucose metabolism and non-alcoholic fatty liver disease severity in morbidly obese women JO - J Endocrinol Invest VL - 37 UR - https://doi.org/10.1007/s40618-014-0101-x DO - 10.1007/s40618-014-0101-x ID - Bedogni2014 ER - TY - JOUR AU - Xu, W. AU - Zhang, X. AU - Wu, J. L. AU - Fu, L. AU - Liu, K. AU - Liu, D. PY - 2017 DA - 2017// TI - O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress JO - J Hepatol VL - 67 UR - https://doi.org/10.1016/j.jhep.2017.03.017 DO - 10.1016/j.jhep.2017.03.017 ID - Xu2017 ER - TY - JOUR AU - Vella, P. AU - Scelfo, A. AU - Jammula, S. AU - Chiacchiera, F. AU - Williams, K. AU - Cuomo, A. PY - 2013 DA - 2013// TI - Tet proteins connect the O-linked N-acetylglucosamine transferase OGT to chromatin in embryonic stem cells JO - Mol Cell VL - 49 UR - https://doi.org/10.1016/j.molcel.2012.12.019 DO - 10.1016/j.molcel.2012.12.019 ID - Vella2013 ER - TY - JOUR AU - Zhang, Y. J. AU - Wu, H. C. AU - Yazici, H. AU - Yu, M. W. AU - Lee, P. H. AU - Santella, R. M. PY - 2012 DA - 2012// TI - Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B1 exposure JO - World J Hepatol VL - 4 UR - https://doi.org/10.4254/wjh.v4.i5.169 DO - 10.4254/wjh.v4.i5.169 ID - Zhang2012 ER - TY - JOUR AU - Greally, J. M. AU - Drake, A. J. PY - 2016 DA - 2016// TI - The current state of epigenetic research in humans JO - JAMA Pediatr VL - 171 UR - https://doi.org/10.1001/jamapediatrics.2016.3508 DO - 10.1001/jamapediatrics.2016.3508 ID - Greally2016 ER - TY - JOUR AU - Huang, Y. AU - Pastor, W. A. AU - Shen, Y. AU - Tahiliani, M. AU - Liu, D. R. AU - Rao, A. PY - 2010 DA - 2010// TI - The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing JO - PLoS One VL - 5 UR - https://doi.org/10.1371/journal.pone.0008888 DO - 10.1371/journal.pone.0008888 ID - Huang2010 ER - TY - JOUR AU - Llufrio, E. M. AU - Wang, L. AU - Naser, F. J. AU - Patti, G. J. PY - 2018 DA - 2018// TI - Sorting cells alters their redox state and cellular metabolome JO - Redox Biol VL - 16 UR - https://doi.org/10.1016/j.redox.2018.03.004 DO - 10.1016/j.redox.2018.03.004 ID - Llufrio2018 ER - TY - JOUR AU - Huang, Q. AU - Tan, Y. AU - Yin, P. AU - Ye, G. AU - Gao, P. AU - Lu, X. PY - 2013 DA - 2013// TI - Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-13-0308 DO - 10.1158/0008-5472.CAN-13-0308 ID - Huang2013 ER - TY - JOUR AU - Rashidi, H. AU - Luu, N. T. AU - Alwahsh, S. M. AU - Ginai, M. AU - Alhaque, S. AU - Dong, H. PY - 2018 DA - 2018// TI - 3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo JO - Arch Toxicol VL - 92 UR - https://doi.org/10.1007/s00204-018-2280-2 DO - 10.1007/s00204-018-2280-2 ID - Rashidi2018 ER - TY - JOUR AU - Younossi, Z. M. AU - Koenig, A. B. AU - Abdelatif, D. AU - Fazel, Y. AU - Henry, L. AU - Wymer, M. PY - 2016 DA - 2016// TI - Global epidemiology of nonalcoholic fatty liver disease—Meta-analytic assessment of prevalence, incidence, and outcomes JO - Hepatology VL - 64 UR - https://doi.org/10.1002/hep.28431 DO - 10.1002/hep.28431 ID - Younossi2016 ER -