Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients

Rubén Fernández-Santiago; Angelika Merkel; Giancarlo Castellano; Simon Heath; Ángel Raya; Eduard Tolosa; María-José Martí; Antonella Consiglio; Mario Ezquerra

doi:10.1186/s13148-019-0701-6

Clinical Epigenetics

Table 1 Gene ontology enrichment analysis of genes annotated to the 5000 top-end statistically most significant unique DMCpGs identified in IPSC-derived DAn from sPD and L2PD patients

From: Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson’s disease patients

Code	Biological processes	p value	FDR
GO:0006928	Movement of cell or subcellular component	6.66E−16	6.06E−12
GO:0040011	Locomotion	5.33E−14	2.42E−10
GO:0022008	Neurogenesis	1.58E−13	4.78E−10
GO:0048646	Anatomical structure formation involved in morphogenesis	2.66E−12	4.38E−09
GO:0048870	Cell motility	2.89E−12	4.38E−09
GO:0051674	Localization of cell	2.89E−12	4.38E−09
GO:0007417	Central nervous system development	4.33E−12	5.49E−09
GO:0009887	Animal organ morphogenesis	5.11E−12	5.49E−09
GO:0030182	Neuron differentiation	5.58E−12	5.49E−09
GO:0048666	Neuron development	6.04E−12	5.49E−09
Code	Cellular component	p value	FDR
GO:0097458	Neuron part	1 < E−17	1 < E−17
GO:0031226	Intrinsic component of plasma membrane	1 < E−17	1 < E−17
GO:0005887	Integral component of plasma membrane	1 < E−17	1 < E−17
GO:0044463	Cell projection part	1 < E−17	1 < E−17
GO:0120038	Plasma membrane-bounded cell projection part	1 < E−17	1 < E−17
GO:0043005	Neuron projection	1 < E−17	1 < E−17
GO:0098590	Plasma membrane region	1 < E−17	1 < E−17
GO:0045202	Synapse	1 < E−17	1 < E−17
GO:0044456	Synapse part	1 < E−17	1 < E−17
GO:0098794	Postsynapse	1 < E−17	1 < E−17
Code	Molecular function	p value	FDR
GO:0008092	Cytoskeletal protein binding	2.34E−07	3.42E−04
GO:0004653	Polypeptide N-acetylgalactosaminyltransferase activity	4.93E−07	3.42E−04
GO:0004714	Transmembrane receptor protein tyrosine kinase activity	7.34E−07	3.42E−04
GO:0001012	RNA polymerase II regulatory region DNA binding	8.79E−07	3.42E−04
GO:0019199	Transmembrane receptor protein kinase activity	9.94E−07	3.42E−04
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	1.25E−06	3.42E−04
GO:0005088	Ras guanyl-nucleotide exchange factor activity	1.28E−06	3.42E−04
GO:0005085	Guanyl-nucleotide exchange factor activity	2.56E−06	6.00E−04
GO:0019904	Protein domain-specific binding	3.30E−06	6.87E−04
GO:0005509	Calcium ion binding	3.85E−06	7.22E−04

Enrichment p values were adjusted by FDR multiple testing correction

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