Table 1 Gene ontology enrichment analysis of genes annotated to the 5000 top-end statistically most significant unique DMCpGs identified in IPSC-derived DAn from sPD and L2PD patients
Code | Biological processes | p value | FDR |
|---|---|---|---|
GO:0006928 | Movement of cell or subcellular component | 6.66E−16 | 6.06E−12 |
GO:0040011 | Locomotion | 5.33E−14 | 2.42E−10 |
GO:0022008 | Neurogenesis | 1.58E−13 | 4.78E−10 |
GO:0048646 | Anatomical structure formation involved in morphogenesis | 2.66E−12 | 4.38E−09 |
GO:0048870 | Cell motility | 2.89E−12 | 4.38E−09 |
GO:0051674 | Localization of cell | 2.89E−12 | 4.38E−09 |
GO:0007417 | Central nervous system development | 4.33E−12 | 5.49E−09 |
GO:0009887 | Animal organ morphogenesis | 5.11E−12 | 5.49E−09 |
GO:0030182 | Neuron differentiation | 5.58E−12 | 5.49E−09 |
GO:0048666 | Neuron development | 6.04E−12 | 5.49E−09 |
Code | Cellular component | p value | FDR |
GO:0097458 | Neuron part | 1 < E−17 | 1 < E−17 |
GO:0031226 | Intrinsic component of plasma membrane | 1 < E−17 | 1 < E−17 |
GO:0005887 | Integral component of plasma membrane | 1 < E−17 | 1 < E−17 |
GO:0044463 | Cell projection part | 1 < E−17 | 1 < E−17 |
GO:0120038 | Plasma membrane-bounded cell projection part | 1 < E−17 | 1 < E−17 |
GO:0043005 | Neuron projection | 1 < E−17 | 1 < E−17 |
GO:0098590 | Plasma membrane region | 1 < E−17 | 1 < E−17 |
GO:0045202 | Synapse | 1 < E−17 | 1 < E−17 |
GO:0044456 | Synapse part | 1 < E−17 | 1 < E−17 |
GO:0098794 | Postsynapse | 1 < E−17 | 1 < E−17 |
Code | Molecular function | p value | FDR |
GO:0008092 | Cytoskeletal protein binding | 2.34E−07 | 3.42E−04 |
GO:0004653 | Polypeptide N-acetylgalactosaminyltransferase activity | 4.93E−07 | 3.42E−04 |
GO:0004714 | Transmembrane receptor protein tyrosine kinase activity | 7.34E−07 | 3.42E−04 |
GO:0001012 | RNA polymerase II regulatory region DNA binding | 8.79E−07 | 3.42E−04 |
GO:0019199 | Transmembrane receptor protein kinase activity | 9.94E−07 | 3.42E−04 |
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | 1.25E−06 | 3.42E−04 |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | 1.28E−06 | 3.42E−04 |
GO:0005085 | Guanyl-nucleotide exchange factor activity | 2.56E−06 | 6.00E−04 |
GO:0019904 | Protein domain-specific binding | 3.30E−06 | 6.87E−04 |
GO:0005509 | Calcium ion binding | 3.85E−06 | 7.22E−04 |