Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

Table 3 Results of top ACPC-associated DMRs separated into those where there was a SNP influencing methylation levels nearby (gDMRs) and those where a nearby associated SNP (ngDMRs) was not found

#chr	Start	End	#DMC	q values, mean	Methdiff, mean	Distance to TSS	Gene name
gDMRs
chr10	43140840	43140878	4	4.68E−06	12	− 6574	ZNF33B
chr13	114579169	114579173	4	6.20E−06	15	7288	LINC00454
chr19	13874993	13875015	4	5.42E−05	− 12	− 324	MRI1
chr4	185189026	185189056	4	0.000174	24	− 49,927	ENPP6
chr12	42539166	42539215	8	6.22E−04	11	− 518	GXYLT1
chr12	124858272	124858284	4	1.03E−03	− 11	− 36,490	MIR6880
chr12	11699957	11700234	22	0.00154	− 14	− 868	LINC01252
chr6	26755655	26755778	6	1.98E−03	12	− 95,737	ZNF322
chr5	171203344	171203485	14	2.31E−03	11	− 9461	SMIM23
chr15	91474603	91474621	4	0.00294	− 10	1187	HDDC3
ngDMRs
chr13	114579169	114579173	4	6.20E−06	15	7288	LINC00454
chr14	24944437	24944579	10	8.84E−05	− 12	32,349	LOC101927045
chr2	1370435	1370661	24	4.05E−04	11	− 46,685	TPO
chr12	42539166	42539215	8	6.22E−04	11	− 518	GXYLT1
chr20	29523738	29524187	27	1.42E−03	− 14	46,400	LINC01598
chr2	91850066	91850070	4	1.71E−03	− 16	− 2093	LOC654342
chr6	26755655	26755778	6	1.98E−03	12	− 95,737	ZNF322
chr7	93996387	93996403	6	2.69E−03	− 11	− 27,478	COL1A2
chr15	91474603	91474621	4	0.00294	− 10	1187	HDDC3
chr14	106865983	106866072	4	3.05E−03	− 10	− 72,417	LINC00221

ISSN: 1868-7083