Models | Phenotype groups | #CpG tested | #DMCs | #hypoDMCs | #hyperDMCs | #DMRs | #hypoDMRs | #hyperDMRs |
---|---|---|---|---|---|---|---|---|
I | ACPA-positive vs. ACPA-negative | 4,733,057 | 2047 | 668 | 1379 | 623 | 210 | 413 |
II | ACPA positive vs. ACPA-negative with cell type adjustment | 4,635,909 | 1909 | 679 | 1230 | 509 | 158 | 351 |
III | Self-reported RA vs. ACPA healthy with cell type adjustment | 4,109,916 | 955 | 435 | 520 | 249 | 81 | 168 |
IV | ACPA ordinal (negative/medium/high) with cell type adjustment | 4,049,218 | 4475 | 869a | 761 | 1303 | 62a | 60 |
V | T cell RA patient vs. controls | 3,262,817 | 1595 | 868 | 727 | 502 | 202 | 300 |