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Table 2 Summary of differentially methylated CpGs from different models

From: Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

Models Phenotype groups #CpG tested #DMCs #hypoDMCs #hyperDMCs #DMRs #hypoDMRs #hyperDMRs
I ACPA-positive vs. ACPA-negative 4,733,057 2047 668 1379 623 210 413
II ACPA positive vs. ACPA-negative with cell type adjustment 4,635,909 1909 679 1230 509 158 351
III Self-reported RA vs. ACPA healthy with cell type adjustment 4,109,916 955 435 520 249 81 168
IV ACPA ordinal (negative/medium/high) with cell type adjustment 4,049,218 4475 869a 761 1303 62a 60
V T cell RA patient vs. controls 3,262,817 1595 868 727 502 202 300
  1. aThe number of hypo/hyper DMCs/DMRs were calculated based on the directional changes of DNA methylation across ACPA-negative, ACPA-medium-positive, and ACPA-high-positive