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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

Fig. 1

Genome-wide distribution of significant CpG sites from EWAS analysis. a qq-plot of the p values from the EWAS associations between ACPA-positive and ACPA-negative after adjustment for cell-type heterogeneity. Genomic control value lambda = 1.05 indicates no obvious inflation. The x-axis indicates the expected −log10 (p values), whereas the y-axis shows the observed −log10 (p values). b Manhattan plot of the p values from the EWAS associations. The x-axis indicates genomic locations of the CpGs, and the y-axis shows −log10 (p values) of the associations

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