Gene | p value (DE) | q value (DE) | log2FC | Best CpG | Chr | Position in bp (hg19a) | Add. CpGs | p value (DM)b | q value (DM) | Δβ/10 SPY |
---|
CYP1B1
| 2.2 × 10−14 | 1.3 × 10−10 | 2.94 | cg01584760 | 2 | 38,296,474 | 6 | 3.8 × 10−10 | 3.1 × 10−4 | − 0.046 |
SLC7A5
| 1.1 × 10−4 | 6.5 × 10−2 | 0.62 | cg10099957 | 16 | 87,869,757 | 2 | 9.6 × 10−6 | 7.1 × 10−2 | − 0.060 |
LAMA3
c
| 0.025 | 0.64 | − 0.20 | cg16113793 | 18 | 21,451,607 | 1 | 1.5 × 10−6 | 4.0 × 10−2 | − 0.027 |
EDC3
| 0.031 | 0.65 | 0.39 | cg17181940 | 15 | 74,948,075 | 1 | 5.6 × 10−6 | 5.9 × 10−2 | − 0.054 |
- Genes nominally significant in the differential expression (DE) analysis that correspond to those CpGs that were associated with smoke pack years (SPY) with q < 0.15 in the differential methylation (DM) analysis and that lie within genetic regions previously reported to be differentially methylated in buccals [22]. EDC3 was additionally reported to be differentially methylated in blood [32]
- aNCBI build GRCh37
- bp values are from the analysis of covariance (ANCOVA) with adjustment by age, sex and batch. DE differential expression, Log2FC log2fold change, Chr chromosome, bp basepairs, Add. CpGs additional CpGs significant with q < 0.15 at this locus, DM differential methylation, SPY smoke pack years
- cEffect sizes for DE and DM are contradictory