A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

Table 5 Differentially expressed transcripts in smokers compared to never smokers

Ensembl gene	Gene symbol	log2 fold change	p value	q value
ENSG00000138061	CYP1B1 ^a	2.9	2.2 × 10⁻¹⁴	4.9 × 10⁻¹⁰
ENSG00000181019	NQO1	1.2	1.2 × 10⁻¹⁰	1.3 × 10⁻⁶
ENSG00000176153	GPX2	1.0	1.0 × 10⁻⁹	7.7 × 10⁻⁶
ENSG00000108602	ALDH3A1	0.9	3.6 × 10⁻⁹	2.0 × 10⁻⁵
ENSG00000140465	CYP1A1 ^a	4.6	2.7 × 10⁻⁸	1.2 × 10⁻⁴
ENSG00000278270	RPS9	2.3	3.1 × 10^− 7	0.0012
ENSG00000164236	ANKRD33B	− 0.7	6.2 × 10⁻⁷	0.0019
ENSG00000167165	UGT1A6	0.8	1.8 × 10⁻⁶	0.0042
ENSG00000171403	KRT9	1.3	1.9 × 10⁻⁶	0.0042
ENSG00000180574	EIF2S3B	− 3.2	1.7 × 10⁻⁶	0.0042
ENSG00000244122	UGT1A7	1.6	3.0 × 10⁻⁶	0.0060
ENSG00000197641	SERPINB13	0.6	3.7 × 10⁻⁶	0.0068
ENSG00000267023		5.2	7.4 × 10⁻⁶	0.0126
ENSG00000124588	NQO2	0.4	1.1 × 10⁻⁵	0.0179
ENSG00000117009	KMO	2.9	1.6 × 10⁻⁵	0.0226
ENSG00000118322	ATP10B	0.5	1.6 × 10⁻⁵	0.0226
ENSG00000284292		− 2.8	2.6 × 10⁻⁵	0.0335
ENSG00000135766	EGLN1	− 0.3	3.0 × 10⁻⁵	0.0368
ENSG00000119938	PPP1R3C	− 0.6	3.2 × 10⁻⁵	0.0375
ENSG00000135299	ANKRD6	− 0.4	4.5 × 10⁻⁵	0.0497

Differential expression analysis based on the RNA-Sequencing data. Log2 fold changes are given for the comparison smokers against never smokers
^aDifferentially methylated in our EWAS with q < 0.05

ISSN: 1868-7083