Skip to main content

Table 4 Change in DNA methylation β values per ten smoking pack years for validated CpGs from the literature

From: A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

CpG identifier

Chr

Position in bp (hg19a)

Gene symbol

Δβ per 10 SPY

p valueb

q value

Associations in buccals and blood

 cg04066994c

5

394,891

AHRR

− 0.04

8.2 × 10−6

0.07

 cg14389122d

15

74,945,851

EDC3

− 0.05

1.3 × 10−5

0.08

 cg17181940c

15

74,948,075

EDC3

− 0.05

5.6 × 10−6

0.06

Associations in buccals

 cg05223638

1

3,036,168

PRDM16

− 0.02

5.6 × 10−5

0.14

 cg27290274

1

15,386,739

KIAA1026

0.00

1.2 × 10−6

0.04

 cg01584760c

2

38,296,474

CYP1B1

− 0.05

3.8 × 10−10

3.2 × 10−4

 cg02162897d

2

38,300,537

CYP1B1

− 0.11

1.2 × 10−7

0.01

 cg20408276d

2

38,300,586

CYP1B1

− 0.11

1.1 × 10−7

0.01

 cg00565882d

2

38,300,707

CYP1B1

− 0.04

1.7 × 10−6

0.04

 cg01410359

2

38,302,230

CYP1B1

− 0.04

3.4 × 10−6

0.05

 cg03890222

2

38,302,487

CYP1B1

− 0.02

6.2 × 10−5

0.15

 cg21715189d

2

38,304,802

CYP1B1

− 0.06

3.2 × 10−5

0.11

 cg06722870

2

236,840,187

AGAP1

0.00

6.0 × 10−5

0.14

 cg04578109c

4

169,475,207

PALLD

− 0.01

1.5 × 10−5

0.08

 cg21490342

6

31,852,301

EHMT2

0.01

6.5 × 10−5

0.15

 cg23076086

6

112,194,849

FYN

− 0.01

2.1 × 10−5

0.09

 cg18873386

7

96,651,915

DLX5

− 0.06

3.4 × 10−5

0.11

 cg11367354

7

96,651,983

DLX5

− 0.05

1.1 × 10−5

0.07

 cg27032146

7

96,652,115

DLX5

− 0.06

2.4 × 10−6

0.04

 cg11500797

7

96,652,123

DLX5

− 0.07

7.1 × 10−6

0.06

 cg11891395

7

96,652,153

DLX5

− 0.10

2.3 × 10−6

0.04

 cg03532926

7

153,584,839

DPP6

0.01

1.3 × 10−5

0.08

 cg06324554

7

157,495,841

PTPRN2

− 0.06

4.9 × 10−5

0.13

 cg02583494c

9

97,640,188

C9orf3

− 0.03

4.2 × 10−5

0.12

 cg22754866

10

99,771,121

CRTAC1

− 0.03

8.5 × 10−6

0.07

 cg15377113

14

93,799,418

BTBD7

0.00

3.0 × 10−6

0.04

 cg12344004

15

89,877,906

POLG

− 0.01

4.1 × 10−5

0.12

 cg10099957

16

87,869,757

SLC7A5

− 0.06

9.6 × 10−6

0.07

 cg09285525

16

87,869,786

SLC7A5

− 0.06

1.3 × 10−5

0.08

 cg27555036

16

87,898,191

SLC7A5

− 0.03

4.5 × 10−5

0.13

 cg13167372d

17

70,536,814

LINC00673

0.03

3.4 × 10−6

0.05

 cg12182124

18

21,451,563

LAMA3

− 0.04

1.9 × 10−6

0.04

 cg16113793

18

21,451,607

LAMA3

− 0.03

1.5 × 10−6

0.04

Associations in blood

 cg06566772c

10

63,661,030

ARID5B

0.00

1.7 × 10−5

0.09

 cg16611234d

11

58,870,075

~ 4.5 kb from FAM111B

− 0.03

3.9 × 10−5

0.12

  1. Shown are results for all CpGs that map to genes previously reported in a large EWAS on buccal swabs [22] or in a systematic review on EWAS on blood [32] and which were associated with SPY in our EWAS with q < 0.15
  2. aNCBI build GRCh37
  3. bp values are from the analysis of covariance (ANCOVA) with adjustment by age, sex and batch. Chr chromosome, bp basepairs, kb kilobasepairs, SPY smoke pack years
  4. cAuxiliary probe on EPIC chip
  5. dSame CpG reported in previous EWAS
Back to article page

Clinical Epigenetics

ISSN: 1868-7083

Contact us