Table 3 Change in DNA methylation β values per ten smoking pack years for significant CpGs
CpG identifier | Chr | Position in bp (hg19a) | Gene symbol | Region | Δβ per 10 SPY | p valueb | q value |
|---|---|---|---|---|---|---|---|
cg09741074 | 1 | 1,310,496 | AURKAIP1 | 5′UTR, 1st Exon | − 0.002 | 8.2 × 10−7 | 3.5 × 10−2 |
cg27290274 | 1 | 15,386,739 | KIAA1026 c | Body | 0.003 | 1.2 × 10−6 | 3.9 × 10−2 |
cg22112416 | 1 | 161,124,001 | UFC1 | Body | − 0.003 | 2.7 × 10−6 | 4.1 × 10−2 |
cg12522303 | 1 | 207,818,368 | CR1L | TSS200 | 0.009 | 2.8 × 10−6 | 4.2 × 10−2 |
cg14686555 | 2 | 6,121,915 | LOC400940 | TSS200 | 0.005 | 2.1 × 10−6 | 4.1 × 10−2 |
cg08502446 | 2 | 36,891,478 |  | Intergenic | − 0.017 | 3.5 × 10−6 | 4.6 × 10−2 |
cg01584760 | 2 | 38,296,474 | CYP1B1 c,d | 3′UTR | − 0.046 | 4.0 × 10−10 | 3.2 × 10−4 |
cg02162897 | 2 | 38,300,537 | CYP1B1 c,d | Body | − 0.110 | 1.1 × 10−7 | 1.3 × 10−2 |
cg20408276 | 2 | 38,300,586 | CYP1B1 c,d | Body | − 0.108 | 1.1 × 10−7 | 1.3 × 10−2 |
cg00565882 | 2 | 38,300,707 | CYP1B1 c,d | Body | − 0.041 | 1.7 × 10−6 | 4.1 × 10−2 |
cg01410359 | 2 | 38,302,230 | CYP1B1 c,d | Body | − 0.037 | 3.6 × 10−6 | 4.6 × 10−2 |
cg26818476 | 2 | 38,337,733 | CYP1B1-AS | Upstream | − 0.021 | 2.3 × 10−6 | 4.1 × 10−2 |
cg10090109 | 2 | 38,338,120 | CYP1B1-AS | Upstream | − 0.015 | 2.1 × 10−8 | 5.9 × 10−3 |
cg17498874 | 2 | 38,460,564 | CYP1B1-AS | Downstream | − 0.062 | 1.1 × 10−6 | 3.9 × 10−2 |
cg04192580 | 2 | 223,726,348 | ACSL3 | 5′UTR | − 0.008 | 1.3 × 10−6 | 4.0 × 10−2 |
cg24985459 | 3 | 37,035,090 | MLH1 | TSS200, 1st Exon | − 0.001 | 2.5 × 10−6 | 4.1 × 10−2 |
cg02748316 | 3 | 50,273,710 | GNAI2 | 5′UTR | − 0.002 | 2.5 × 10−6 | 4.1 × 10−2 |
cg04859961 | 3 | 131,951,282 | CPNE4; tRNACys | Body | 0.024 | 2.6 × 10−6 | 4.1 × 10−2 |
cg11344771 | 3 | 188,108,786 | LPP | 5′UTR | − 0.020 | 6.5 × 10−7 | 3.1 × 10−2 |
cg26094150 | 5 | 79,378,871 | THBS4 | Body | − 0.003 | 2.9 × 10−7 | 2.2 × 10−2 |
cg24179483 | 5 | 170,814,656 | NPM1 | TSS200 | − 0.002 | 3.1 × 10−6 | 4.3 × 10−2 |
cg09575472 | 5 | 174,045,109 |  | Intergenic | − 0.032 | 2.0 × 10−6 | 4.1 × 10−2 |
cg07471462 | 6 | 33,168,624 | SLC39A7 | 1stExon, 5′UTR | − 0.002 | 1.8 × 10−6 | 4.1 × 10−2 |
cg13273398 | 6 | 116,937,346 | RSPH4A | TSS1500 | − 0.018 | 2.7 × 10−6 | 4.1 × 10−2 |
cg26902259 | 6 | 126,102,246 | NCOA7 | TSS200 | − 0.008 | 2.6 × 10−6 | 4.1 × 10−2 |
cg02363875 | 7 | 960,707 | ADAP1 | TSS200 | 0.003 | 1.7 × 10−6 | 4.1 × 10−2 |
cg18526602 | 7 | 6,487,739 | DAGLB | TSS200 | − 0.002 | 2.0 × 10−6 | 4.1 × 10−2 |
cg20231669 | 7 | 22,862,119 | TOMM7 | Body | − 0.005 | 9.2 × 10−8 | 1.3 × 10−2 |
cg01858449 | 7 | 33,551,455 | BBS9 | Body | − 0.020 | 6.2 × 10−7 | 3.1 × 10−2 |
cg27032146 | 7 | 96,652,115 | DLX5 c | Body | − 0.062 | 2.4 × 10−6 | 4.1 × 10−2 |
cg11891395 | 7 | 96,652,153 | DLX5 c | Body | − 0.097 | 2.5 × 10−6 | 4.1 × 10−2 |
cg21757062 | 7 | 121,376,168 | 329 bp from 7SK | Intergenic | − 0.027 | 1.5 × 10−6 | 4.1 × 10−2 |
cg00924357 | 7 | 131,012,552 | MKLN1 | Body | − 0.001 | 2.6 × 10−6 | 4.1 × 10−2 |
cg16171205 | 7 | 152,135,221 | FABP5P3 | Body | − 0.047 | 3.0 × 10−7 | 2.2 × 10−2 |
cg15821835 | 8 | 67,686,767 | SGK3 | TSS1500 | − 0.006 | 2.3 × 10−6 | 4.1 × 10−2 |
cg07234508 | 8 | 82,395,948 | FABP4 | TSS1500 | − 0.073 | 1.1 × 10−6 | 3.9 × 10−2 |
cg15845333 | 8 | 144,417,025 | TOP1MT | 1stExon | − 0.003 | 1.6 × 10−7 | 1.6 × 10−2 |
cg14519682 | 9 | 130,213,309 | LRSAM1 | TSS1500 | − 0.002 | 8.0 × 10−7 | 3.5 × 10−2 |
cg02030592 | 10 | 22,863,044 | PIP4K2A | Body | − 0.106 | 5.3 × 10−7 | 3.1 × 10−2 |
cg09823091 | 10 | 94,644,717 | EXOC6 | Body | −0.033 | 1.8 × 10−7 | 1.6 × 10−2 |
cg08206898 | 10 | 116,581,183 | FAM160B1 | TSS1500 | − 0.016 | 2.2 × 10−6 | 4.1 × 10−2 |
cg27009448 | 10 | 120,492,138 | C10orf46 | Body | − 0.046 | 3.0 × 10−6 | 4.3 × 10−2 |
cg12106634 | 11 | 108,092,400 | ATM | TSS1500 | − 0.006 | 1.2 × 10−6 | 3.9 × 10−2 |
cg06531661 | 12 | 57,522,120 | LRP1 | TSS200 | −0.002 | 1.1 × 10−7 | 1.3 × 10−2 |
cg13016115 | 14 | 23,388,406 | RBM23 | TSS200 | − 0.002 | 1.3 × 10−6 | 4.0 × 10−2 |
cg24151229 | 14 | 93,260,858 | GOLGA5 | 5’UTR | − 0.002 | 3.6 × 10−6 | 4.6 × 10−2 |
cg15377113 | 14 | 93,799,418 | BTBD7 c | TSS200 | − 0.001 | 3.1 × 10−6 | 4.3 × 10−2 |
cg12361883 | 14 | 104,313,596 | LINC00637 | TSS1500 | − 0.002 | 6.4 × 10−7 | 3.1 × 10−2 |
cg26693173 | 15 | 33,137,114 | FMN1 | Body | − 0.015 | 2.2 × 10−8 | 5.9 × 10−3 |
cg09167084 | 15 | 40,861,240 | RPUSD2 | TSS1500 | − 0.008 | 1.1 × 10−6 | 3.9 × 10−2 |
cg04928180 | 15 | 99,791,525 | LRRC28 | TSS200 | − 0.001 | 2.3 × 10−6 | 4.1 × 10−2 |
cg07984365 | 16 | 739,425 | WDR24 | 1stExon | 0.011 | 2.5 × 10−6 | 4.1 × 10−2 |
cg21737024 | 16 | 30,441,289 | DCTPP1 | 1stExon | − 0.003 | 3.8 × 10−7 | 2.6 × 10−2 |
cg12642651 | 17 | 9,861,712 | GAS7 | Body | − 0.022 | 3.6 × 10−6 | 4.6 × 10−2 |
cg13167372 | 17 | 70,536,814 | LINC00673 c,d | Gene body | 0.027 | 2.2 × 10−6 | 4.1 × 10−2 |
cg12182124 | 18 | 21,451,563 | LAMA3 c | TSS1500 | − 0.040 | 2.2 × 10−6 | 4.1 × 10−2 |
cg16113793 | 18 | 21,451,607 | LAMA3 c | TSS1500 | − 0.028 | 1.8 × 10−6 | 4.1 × 10−2 |
cg19328682 | 18 | 47,807,700 | MBD1 | 5’UTR | − 0.004 | 6.1 × 10−7 | 3.1 × 10−2 |
cg27308982 | 18 | 77,196,450 | NFATC1 | Body, 5’UTR | − 0.012 | 1.1 × 10−6 | 3.9 × 10−2 |
cg02693125 | 20 | 23,401,585 | NAPB | Body | − 0.006 | 1.9 × 10−6 | 4.1 × 10−2 |
cg18411827 | 22 | 23,412,613 | GNAZ | TSS200 | − 0.003 | 1.4 × 10−6 | 4.0 × 10−2 |