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Table 2 Change in DNA methylation β values for smokers compared to never smokers

From: A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

CpG identifier

Chr

Position in bp (hg19a)

Gene symbol

Region

Δβ

p valueb

q value

cg02162897

2

38,300,537

CYP1B1 c

Body

− 0.183

5.5 × 10−8

0.022

cg20408276

2

38,300,586

CYP1B1 c

Body

− 0.176

3.6 × 10−7

0.040

cg24752487

2

38,324,188

21 kb upstream of CYP1B1c

Intergenic; Mammalian H3K27me3-repression mark

− 0.138

2.1 × 10−7

0.040

cg06036945

5

394,869

AHRR c

Body

− 0.125

3.7 × 10−7

0.040

cg04066994

5

394,891

AHRR c

Body

− 0.083

5.9 × 10−10

4.7 × 10−4

cg20385913

15

75,054,510

6 kb downstream of CYP1A2

intergenic

− 0.063

3.1 × 10−7

0.040

cg02123605

17

70,497,550

LINC00673 c

Body

− 0.056

4.0 × 10−7

0.040

cg23167235

17

70,532,667

LINC00673 c

Body

− 0.018

4.7 × 10−7

0.042

cg23398508

17

70,536,199

LINC00673 c

Body

− 0.098

1.1 × 10−7

0.030

  1. Shown are results for all CpGs significant after correction for multiple testing (q < 0.05). For comparison, we additionally included the results from the SPY analysis for significant CpGs
  2. aNCBI build GRCh37
  3. bp values are from the analysis of covariance (ANCOVA) with adjustment by age, sex and batch. Chr chromosome, bp basepairs, SPY smoke pack years, kb kilobasepairs
  4. cGenetic region previously reported to be associated with smoking in buccals [22]