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Fig. 6 | Clinical Epigenetics

Fig. 6

From: A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers

Fig. 6

Gene expression of CYP1B1 and CYP1B1-AS is significantly increased by cigarette smoke extract in vitro. Primary gingival fibroblast cell lines were cultured from three independent ex vivo biopsies (FB1–3) and treated for 6 h with cigarette smoke extract (CSE), labelled as “+”. Control cell lines without CSE treatment are labelled as “−”. qRT-PCR data were obtained from five treatments with CSE. Significant upregulation upon CSE treatment were observed for CYP1B1 (padj = 0.019) and CYP1B1-AS (padj = 0.023). P values are Bonferroni-adjusted for two independent tests

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Clinical Epigenetics

ISSN: 1868-7083

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