Skip to main content

Table 9 ASSURE patient plasma: IPA® diseases and biological functions identified in the analysis of the patient plasma proteome

From: Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Diseases and bio functions

Ingenuity® Pathway Analysis

z-score

p value

Response of granulocytes

− 2.9

1.8 × 10−13

Interaction of mononuclear leukocytes

− 2.9

5.4 × 10−13

Interaction of leukocytes

− 2.8

3.7 × 10−26

Binding of mononuclear leukocytes

− 2.8

1.4 × 10−12

Binding of leukocytes

− 2.7

2.4 × 10−25

Response of myeloid cells

− 2.6

7.0 × 10−15

Adhesion of mononuclear leukocytes

− 2.6

7.8 × 10−11

Response of myeloid leukocytes

− 2.5

1.7 × 10−14

Response of neutrophils

− 2.5

5.9 × 10−12

Adhesion of blood cells

− 2.4

4.0 × 10−23

Outgrowth of cells

− 2.4

1.1 × 10−10

Neovascularization

− 2.4

2.5 × 10−08

Interaction of lymphocytes

− 2.4

2.0 × 10−11

Interaction of blood cells

− 2.4

4.7 × 10−27

Migration of tumor cell lines

− 2.4

1.5 × 10−20

Vascularization

− 2.3

1.4 × 10−10

Colony formation

− 2.3

9.7 × 10−09

Binding of blood cells

− 2.3

3.2 × 10−26

Binding of lymphocytes

− 2.3

4.6 × 10−11

Adhesion of immune cells

− 2.2

1.4 × 10−23

Cell death

− 2.2

3.4 × 10−34

Growth of neurites

− 2.2

7.6 × 10−10

Colony formation of cells

− 2.2

2.1 × 10−08

  1. Positive activation z-scores reflect the predicted activation of a disease or function (significant when > ~ 2)
  2. Negative activation z-scores reflect the predicted suppression of a disease or function (significant when < ~− 2)
  3. P value reflects the overlap between the genes in the data set that are significantly affected by treatment (> 10% change, p < 0.05) and the genes that are in the diseases and function category
  4. Italicized pathways have direct associations with vascular inflammation