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Table 5 HUVEC Nanostring: IPA® diseases and biological functions identified TNFα-activated processes inhibited by apabetalone

From: Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Diseases and biological functions

Ingenuity® Pathway Analysis

z-score

TNFα

Apabetalone

5 μM

Apabetalone

20 μM

Migration of cells

6.0

− 1.4

− 4.1

Cell movement

5.9

− 1.2

− 4.2

Migration of tumor cells

5.4

− 2.4

− 3.8

Cell movement of phagocytes

5.4

− 1.1

− 3.4

Activation of cells

5.3

− 2.2

− 3.4

Cell movement of tumor cells

5.3

− 1.7

− 3.5

Activation of blood cells

5.3

− 1.8

0

Homing of cells

5.2

− 1.0

− 3.5

Cell movement of myeloid cells

5.2

− 0.8

− 3.4

Activation of leukocytes

5.2

− 1.7

− 3.0

Chemotaxis

5.2

− 0.9

− 3.4

Cell movement of leukocytes

5.1

− 0.7

− 3.3

Leukocyte migration

5.1

− 0.8

− 3.2

Activation of phagocytes

4.9

− 1.9

− 3.1

Activation of myeloid cells

4.7

− 1.4

− 3.1

Activation of mononuclear leukocytes

4.5

− 0.8

− 2.6

Migration of phagocytes

4.4

− 1.2

− 2.7

Quantity of cells

4.4

− 1.3

− 2.0

Chemotaxis of myeloid cells

4.4

− 0.8

− 2.7

Attraction of cells

4.4

− 0.8

− 3.1

Recruitment of cells

4.4

− 1.0

− 2.9

Expression of RNA

4.4

− 1.7

− 3.4

Transcription

4.4

− 1.3

− 3.0

Inflammatory response

4.3

− 1.5

− 3.4

  1. Positive activation z-scores reflect the predicted activation of a disease or function (significant when > ~ 2)
  2. Negative activation z-scores reflect the predicted suppression of a disease or function (significant when < ~− 2)