Table 4 HUVEC Nanostring: IPA® canonical pathway analysis identified TNFα-activated pathways inhibited by apabetalone
IPA canonical pathways | |||
|---|---|---|---|
Ingenuity® Pathway Analysis | z-score | ||
TNFα | Apabetalone 5 μM | Apabetalone 20 μM | |
TREM1 signaling | 3.8 | − 1.8 | − 3.1 |
Acute phase response signaling | 3.8 | − 1.6 | − 3.1 |
SAPK/JNK signaling | 3.7 | − 1.3 | − 2.8 |
IL-6 signaling | 3.7 | − 0.8 | − 2.2 |
Dendritic cell maturation | 3.7 | − 2.2 | − 4.0 |
HGF signaling | 3.6 | − 0.5 | − 2.1 |
Neuroinflammation signaling pathway | 3.6 | − 1.6 | − 2.1 |
Renin-angiotensin signaling | 3.5 | 0.4 | − 2.1 |
HMGB1 signaling | 3.4 | − 1.2 | − 2.2 |
NF-κB signaling | 3.4 | − 1.4 | − 2.9 |