Table 3 HUVEC Nanostring: IPA® upstream regulator analysis predicted that endotoxin, cytokine, and TLR signaling regulators are inhibited by apabetalone
IPA upstream regulators | ||||
|---|---|---|---|---|
Ingenuity® Pathway Analysis | Target | z-score | ||
TNFα | Apabetalone 5 μM | Apabetalone 20 μM | ||
Endotoxin | LPS | 6.3 | − 3.3 | − 4.4 |
Cytokines | TNFα | 6.1 | − 2.6 | − 4.2 |
NF-κB (complex) | 5.9 | − 2.7 | − 3.5 | |
IL-1β | 5.4 | − 1.9 | − 3.3 | |
IL-1α | 4.9 | − 2.2 | − 1.8 | |
RELA | 4.8 | − 1.9 | − 2.7 | |
IFNG | 4.3 | − 2.9 | − 4.0 | |
IL-6 | 2.6 | − 1.6 | − 1.5 | |
TLR signaling | TLR4 | 5.3 | − 3.3 | − 4.4 |
TICAM1 | 5.1 | − 2.7 | − 4.5 | |
MYD88 | 5.1 | − 3.1 | − 4.1 | |
TLR3 | 5.0 | − 3.3 | − 3.5 | |