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Table 2 HUVEC NanoString: apabetalone reduces the expression of pro-atherogenic genes upregulated by TNFα

From: Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Function

Gene

TNFα

Fold induction

% reduction

Control

Apabetalone

5 μM

20 μM

Chemokine

MCP-1p

133

− 18

− 65

CXCL10p

86

− 78

− 84

CXCL3

820

11

− 32

IL-8p

185

− 47

− 79

Cytokine

CSF-2

154.6

− 76

− 93

IL-1βp

3.0

− 64

− 66

IL-15p

31.6

− 59

− 87

IL-18p

8.4

65

− 25

IL-6p

9.6

− 59

− 90

LTBp

119.3

− 77

− 99

TGFB3

23.5

− 30

− 88

TNF

14.6

− 93

− 93

Transcription factor

IRF1p

7.9

− 26

− 42

RELB

14.4

− 15

− 30

Receptor and Adaptors

TLR2p

28.9

− 52

− 78

IL-1R

3.2

− 47

− 72

MYD88

1.3

− 3

− 41

TRADD

2.4

10

− 35

Enzymes

C1Sp

11.1

− 90

− 91

CFBp

72.6

− 64

− 87

COX-2

8.5

− 59

− 93

IFIT2p

11.1

− 23

− 15

TNFAIP3

80.5

− 28

− 51

  1. PGenes involved in plaque stability