Function | Gene | TNFα | ||
---|---|---|---|---|
Fold induction | % reduction | |||
Control | Apabetalone | |||
5 μM | 20 μM | |||
Chemokine | MCP-1p | 133 | − 18 | − 65 |
CXCL10p | 86 | − 78 | − 84 | |
CXCL3 | 820 | 11 | − 32 | |
IL-8p | 185 | − 47 | − 79 | |
Cytokine | CSF-2 | 154.6 | − 76 | − 93 |
IL-1βp | 3.0 | − 64 | − 66 | |
IL-15p | 31.6 | − 59 | − 87 | |
IL-18p | 8.4 | 65 | − 25 | |
IL-6p | 9.6 | − 59 | − 90 | |
LTBp | 119.3 | − 77 | − 99 | |
TGFB3 | 23.5 | − 30 | − 88 | |
TNF | 14.6 | − 93 | − 93 | |
Transcription factor | IRF1p | 7.9 | − 26 | − 42 |
RELB | 14.4 | − 15 | − 30 | |
Receptor and Adaptors | TLR2p | 28.9 | − 52 | − 78 |
IL-1R | 3.2 | − 47 | − 72 | |
MYD88 | 1.3 | − 3 | − 41 | |
TRADD | 2.4 | 10 | − 35 | |
Enzymes | C1Sp | 11.1 | − 90 | − 91 |
CFBp | 72.6 | − 64 | − 87 | |
COX-2 | 8.5 | − 59 | − 93 | |
IFIT2p | 11.1 | − 23 | − 15 | |
TNFAIP3 | 80.5 | − 28 | − 51 |