Clinical Epigenetics

Table 1 Apabetalone suppresses stimulant-induced transcripts of HUVEC cytokine, chemokine, TLR signaling, and adhesion molecules

From: Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Function	Gene	TNFα			IL-1β			LPS
		Fold induction	% reduction		Fold induction	% reduction		Fold induction	% reduction
		Control	Apabetalone		Control	Apabetalone		Control	Apabetalone
		Control	5 μM	20 μM	Control	5 μM	20 μM	Control	5 μM	20 μM
Enzyme	COX-2	4	NS	− 86	19	− 46	− 85	NI	− 42	− 83
Cytokine	CSF-2	945	− 82	− 98	8096	− 59	− 91	9	− 64	− 85
	IL-1β	1685	− 90	− 99	ND	ND	ND	ND	ND	ND
	IL-6	9	− 51	− 91	191	− 54	− 84	1.6	− 67	− 69
	IL-8	26	ND	− 48	ND	ND	ND	ND	ND	ND
	OPG	43	− 95	− 99	142	− 96	− 99	1.4	− 71	− 84
Chemokine	MCP-1	40	− 21	− 71	44	− 35	− 62	4	− 50	− 82
TLR signaling	MYD88	NI	NS	− 56	NI	− 30	− 66	1.6	− 44	− 38
Adhesion molecules	CD44	2	NS	− 34	3	NS	NS	NI	− 33	− 34
	SELE	1164	NS	− 54	368	− 17	− 40	11	− 51	− 76
	VCAM-1	196	− 59	− 83	96	− 72	− 91	6	− 73	− 96

NS no signal, NI no induction, ND not determined

Back to article page

ISSN: 1868-7083

Contact us

Submission enquiries: avalyn.villar@springernature.com
General enquiries: info@biomedcentral.com