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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

Fig. 5

In THP-1 cells, MZ-1 and apabetalone prevent TNFα induction of key inflammatory and adhesion marker transcripts. a MZ-1 (6 h; 1 μM) degrades THP-1 BRD2, BRD3, and BRD4 as shown by western blot. b–d TNFα stimulation (2 h) fails to induce transcription of IL-1β (b), MCP-1 (c), or MYD88 (d) following MZ-1 pretreatment (6 h). Apabetalone (20 μM) pretreatment (6 h) decreases the transcripts of these genes. Statistical significance was determined through 1-way ANOVA analysis followed by Dunnett’s Multiple Comparison Test using TNFα response for the comparison, where *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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