Clustered protocadherins methylation alterations in cancer

Clinical Epigenetics

Table 3 Altered CGIs in gastric cancer

UCSC CGI	UCSC CGI name	CTCF binding site	Δβ value (GC-control)	Genes within region	Gene promoter-associated CGI
chr5:140762401-140762768	CpG 28	chr5:140761029-140763470	0.241	PCDHGA1, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGB1, PCDHGB2, PCDHGB3	PCDHGA7
chr5:140787447-140788044	CpG 45	chr5:140786247-140788714	0.210	PCDHGA1, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGA8, PCDHGA9, PCDHGB1, PCDHGB2, PCDHGB3, PCDHGB4, PCDHGB5, PCDHGB6	PCDHGB6
chr5:140855386-140856620	CpG 95	chr5:140854218-140856648	0.212	PCDHGA1, PCDHGA10, PCDHGA11, PCDHGA12, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGA8, PCDHGA9, PCDHGB1, PCDHGB2, PCDHGB3, PCDHGB4, PCDHGB5, PCDHGB6, PCDHGB7, PCDHGC3	PCDHGC3
chr5:140864527-140864748	CpG 22	–	0.243	PCDHGA1, PCDHGA10, PCDHGA11, PCDHGA12, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGA8, PCDHGA9, PCDHGB1, PCDHGB2, PCDHGB3, PCDHGB4, PCDHGB5, PCDHGB6, PCDHGB7, PCDHGC3, PCDHGC4	PCDHGC4

Note: CGI CpG island, GC gastric cancer. CpG 28, 45, 95 and 22 correspond to UCSC CGI name

ISSN: 1868-7083