Fig. 6

Gastric discovery set unsupervised hierarchical clustering analysis based on the average methylation β value for each of the aberrantly methylated CGI. Heatmap obtained by UHC of 22 gastric cancer samples and their matched normal samples. A group of GC with high methylation values branched together separated from normal samples and few GC samples that resembled the methylation pattern of controls. The UHC analysis also revealed another group of GC with a methylation profile between normal and tumour samples. To the right of the heatmap, further information are reported: histology, localization and subtype. GC gastric cancer, MSI microsatellite instability, CIN chromosomal instability, GS genomic stability