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Table 2 Univariate Cox proportional hazards analysis of BCR-free survival in TCGA cohort including PC patients treated by radical prostatectomy

From: SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy

Variable

P value

Hazard ratio [95% CI]

Age (> 60 vs. ≤ 60)

0.8385

0.944 [0.545, 1.637]

pT3-4 vs. pT2

< 0.001

7.266 [2.617, 20.172]

pN1 vs. pN0

0.025

2.045 [1.094, 3.823]

Gleason score

< 0.001

4.244 [2.256, 7.981]

Preoperative PSA

0.0015

1.025 [1.009, 1.04]

R1 vs. R0

0.0231

1.902 [1.092, 3.312]

SLCO4C1 methylation

 cg06480736 (continuous)

< 0.001

15.914 [3.863, 65.565]

 cg19774478 (continuous)

< 0.001

9.001 [2.789, 29.054]

 cg19788741 (continuous)

0.003

10.759 [2.203, 52.553]

 cg22149516 (continuous)

0.006

17.144 [2.295, 128.066]