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Table 1 Correlation between SLCO4C1 DNA promoter methylation and clinicopathological parameters

From: SLCO4C1 promoter methylation is a potential biomarker for prognosis associated with biochemical recurrence-free survival after radical prostatectomy

Variable

All patients

cg22149516

(P value)

cg06480736

(P value)

cg19788741

(P value)

cg19774478

(P value)

Patient number

498

    

Age (years)

 > 60

247

    

 ≤ 60

251

0.09a

0.04a

0.03a

0.36a

Tumour category

 pT2

188

    

 pT3 and pT4

303

    

 Unknown

7

0.02a

< 0.01a

< 0.01a

< 0.01a

Gleason score

 < 7

45

    

 3 + 4

147

    

 4 + 3

101

    

 = 8

64

    

 > 8

141

0.28a

< 0.01a

< 0.01a

< 0.01a

Surgical margin

 R0

316

    

 R1, R2 and RX

162

    

 Unknown

20

0.06a

< 0.01a

< 0.01a

0.02a

Nodal category

 pN0

346

    

 pN1

79

    

 Unknown

73

0.18a

0.02a

0.01a

0.01a

Preoperative PSA [ng/ml]

 0~4

51

    

 4–10

286

    

 > 10

153

    

 Unknown

8

0.64b

0.28b

0.42b

0.25b

  1. aMann-Whitney U test
  2. bKruskal-Wallis test