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Table 1. Analyzed pregnancy cases and study material

From: Parent-of-origin-specific allelic expression in the human placenta is limited to established imprinted loci and it is stably maintained across pregnancy

 

Terminated pregnancya

Term pregnancy

First trimester

Second trimester

Normal

SGA

LGA

PE

GD

Pregnancy-specific variables

Gestational age (days)

60.0

(51–81)

138.0

(126–167)

284.0

(260–291)

268.5

(264–289)

280.5

(275–288)

266.0

(260–271)

275.5

(268–284)

Offspring sex, F/M (n)

4/4

3/3

3/5

5/3

4/4

4/4

5/3

C-sect/vaginal delivery (n)

–

–

5/3

6/2

3/5

2/6

3/5

Maternal age

(years)

25.5

(18–33)

23.0

(15–36)

33.0

(18–37)

24.5

(20–32)

30.0

(23–39)

26.5

(19–39)

32.5

(22–36)

Paternal age

(years)

n.a.

n.a.

34.0

(22–38)

26.0

(23–39)

35.5

(23–50)

32

(21–46)

34

(22–43)

Study material—placental and parental blood samples

Samples

Chorion

Full-thickness samples from the middle region of placenta

Mat/Pat/Pl (n)

–

–

8

7

7

8

8

Mat/Pl (n)

8

6

–

1

1

–

–

  1. Data is presented as median (range), if not indicated otherwise. Detailed information on the analyzed pregnancy cases is presented in Additional file 2: Table S1 and Additional file 3: Table S2
  2. aChorionic villi from first trimester placentas were sampled after elective surgical termination of pregnancy. Samples of second trimester placentas were derived from cases of medically induced abortion due to maternal health indications
  3. C-sect, Cesarean delivery; GD, gestational diabetes; LGA, delivery of a large-for-gestational-age newborn; normal, term pregnancy without any maternal or fetal complications; PE, preeclampsia; SGA, delivery of a small-for-gestational-age newborn; F, female; M, male; n, number; n.a., not available; Mat, maternal blood sample; Pat, maternal blood sample; Pl, placental sample
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Clinical Epigenetics

ISSN: 1868-7083

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