Skip to main content

Table 2. Hypermethylated promoter island probes showing largest differences between SSAD backgrounds and SSAs

From: DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas

Probe Gene Methylation logFC (SSAD background vs. SSA)* Adjusted P value
Most hypermethylated probes  
 cg21016956 NOL4 1.493751 0.000787
 cg16916433 ADAMTS19 1.392486 0.002431
 cg07733457 ZNF594 1.363048 0.002957
 cg20388206 NOL4 1.290463 0.002242
 cg08624472 ARPC1B 1.253215 0.040197
 cg08326075 SV2B 1.251781 0.003033
 cg16552945 ARHGDIG 1.233535 0.007083
 cg14933485 PGR 1.200440 0.000873
 cg06520273 CCDC39 1.198272 0.004478
 cg07352001 ZNF32 1.197676 0.010383
 cg24713878 P2RX5 1.195933 0.037569
 cg27331401 MLH1/EPM2AIP1 1.194737 0.022763
 cg15353810 C16orf62 1.190115 0.005143
 cg17210604 HIC1 1.180987 0.031011
 cg11224603 MLH1/EPM2AIP1 1.163986 0.004474
 cg22308600 NOL4 1.163516 0.005631
 cg22715021 CLPSL2 1.157144 0.035127
 cg27586588 MLH1/EPM2AIP1 1.154898 0.048775
 cg12609243 CACNA2D3 1.148465 0.002208
 cg11555122 ZNF594 1.142647 0.005650
Most statistically significant probes  
 cg16709874 RCOR3 1.017873 0.000382
 cg21016956 NOL4 1.493751 0.000787
 cg14933485 PGR 1.200440 0.000873
 cg19809077 GTF2H4/VARS2 0.751390 0.000897
 cg23546619 BCAS3 0.717448 0.001064
 cg17360299 MYCN 0.783056 0.001130
 cg06925115 ATP2B2 0.718108 0.001319
 cg26691477 EN1 0.714066 0.001326
 cg05116343 BAIAP3 0.902199 0.001433
 cg24727182 ETNPPL 0.748564 0.001561
 cg02357389 CCDC59/METTL25 0.958562 0.001634
 cg09647147 OGDHL 0.959377 0.001654
 cg07774938 CCDC180 0.880026 0.001682
 cg11680300 AUTS2 1.135098 0.001693
 cg02945056 GCC1 0.831327 0.001795
 cg00142257 LHX6 0.789183 0.001795
 cg04987474 HDHD3 0.561859 0.001948
 cg21267231 DUOX2 0.557276 0.002008
 cg09982069 XPO4 0.909124 0.002033
 cg10043101 ATP1B2 0.940714 0.002133
  1. *A methylation logFC value of > 0 indicates hypermethylation in SSAD background compared with SSA. SSAD sessile serrated adenoma with dysplasia, SSA sessile serrated adenoma