Experimental design. An SSA progresses to SSAD and then to BRAF-mutant CIMP-high microsatellite unstable CRC. Within SSADs, the SSAD background represents the most advanced SSA prior to dysplasia and should also demonstrate methylation differences from ordinary SSAs. Asterisks indicate data obtained from previous studies. *Data obtained from Liu et al. ; all SSAs were also required to be MLH1 unmethylated via MethyLight for inclusion in the current study. **Data obtained from Liu et al. . ***Data obtained from Dumenil et al. . ****Data obtained from Fennell et al. . CRC, colorectal cancer; SSAD, sessile serrated adenoma with dysplasia; SSA, sessile serrated adenoma; CIMP, CpG island methylator phenotype; EPIC, Illumina MethylationEPIC platform; 450K, Illumina HumanMethylation450 platform; HumanHT-12, Illumina HumanHT-12 v3 Expression platform; IHC, immunohistochemistry.