Fig. 1

ARID1A protein loss in human cancer samples is consistent with mutation rates. ARID1A is mutated in up to ~ 12% colorectal cancers from different colorectal cancer cohorts [3, 4] (a). Representative immunohistochemical staining images show clear ARID1A staining in the rectal mucosa and positive tumors while negative tumors show no staining at all (b). The University Medical Center Gӧttingen rectal cancer cohort showed 81.7% strongly positive ARID1A staining (++) and 3.7% showed weakly positive staining (+) while 14.6 % of the samples were negative for ARID1A staining (c)