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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Comprehensive DNA methylation analysis of tissue of origin of plasma cell-free DNA by methylated CpG tandem amplification and sequencing (MCTA-Seq)

Fig. 1

Genome-wide DNA methylation comparison between plasma and WBC. a Schematic diagram of the strategy for a systematic and unbiased examination of the non-hematopoietic tissue of origin of plasma cfDNA. b Volcano plot showing differentially methylated CGCGCGGs (dmCGCGCGGs) between plasma and WBC. The x-axis shows the fold change of the average methylation value between plasma cfDNA and WBC gDNA, and the y-axis shows the q value as the FDR analog of the P value (−Log10(q value)) for a two-tailed MWW test of differences between two groups. The horizontal gray line indicates statistical significance (FDR < 0.05). c A heatmap showing methylation of the dmCGCGCGGs in different tissues and 14 paired WBC and plasma samples. d, e Boxplots of the dmCGCGCGGs showing d the methylation values (methylated alleles per million mapped reads, MePM) of MCTA-Seq or e the methylation levels in the published DNA methylome data

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